CTLA4 - cytotoxic T-lymphocyte associated protein 4 Gene

Bos taurus

Also known as CD152; CTLA-4

Gene ID: 281732 | Gene type: protein coding

About CTLA4

Primary_assembly 2: 92,070,614-92,077,168 forward strand.ARS-UCD1.2:CM008169.2

This gene has 1 transcript (splice variant), 157 orthologues and 1 paralogue.

mRNA	Protein	Name
NM_174297.1	NP_776722.1	cytotoxic T-lymphocyte protein 4 precursor

Protein Preferred Names

Protein Names

cytotoxic T-lymphocyte protein 4

cytotoxic T-lymphocyte antigen 4

Approval

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108829	Abatacept		≥99.0%	Unkown
HY-P9901	Ipilimumab	Inhibitor	99.88%	Unkown
HY-P9918	Tremelimumab		99.50%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-159692	AZD8701	Inhibitor	96.61%	Phase 1

Inhibitory Antibodies (17)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108829A	Abatacept (powder)	Inhibitor	99.01%	Phase 4
HY-P99540	Tuvonralimab	Inhibitor	99.14%	Phase 4
HY-P99117	Cadonilimab	Inhibitor	99.87%	Phase 3
HY-P990690	Volrustomig	Inhibitor	≥99.0%	Phase 3
HY-P990042	Gotistobart	Inhibitor	≥99.0%	Phase 3
HY-P99484	Botensilimab	Inhibitor	99.00%	Phase 3
HY-P99943	Erfonrilimab		99.98%	Phase 3
HY-P99166	Vudalimab	Inhibitor	≥99.0%	Phase 2
HY-P99714	Lorigerlimab	Inhibitor	97.5%	Phase 2
HY-P99514	Zalifrelimab	Inhibitor	98.28%	Phase 2
HY-P99809	Quavonlimab	Inhibitor	≥99.0%	Phase 2
HY-P990739	Evalstotug		95.062%	Phase 2
HY-P990775	Vilastobart		99.63%	Phase 2
HY-P990703	Porustobart		99.70%	Phase 1
HY-P990041	Firastotug	Inhibitor	98.62%	Phase 1
HY-P99844	Davoceticept		99.9%	Phase 1
HY-P99760	Nurulimab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120120	DZ-2384	Inhibitor	/	Unkown
HY-122081	CPI-644	Inhibitor	/	Unkown
HY-RS03299	CTLA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03300	Ctla4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03301	Ctla4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179228	AN02		/	Unkown

Inhibitory Antibodies (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99132	Anti-Mouse CTLA-4 Antibody (9D9)	Inhibitor	≥98.0%	Unkown
HY-P990789	Anti-Mouse CTLA-4 Antibody (9H10)	Inhibitor	99%	Unkown
HY-P990256	Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)	Inhibitor	98.68%	Unkown
HY-P990048	Muzastotug	Inhibitor	99.48%	Unkown
HY-P990080	Sovipostobart	Inhibitor	96.528%	Unkown
HY-P990945	Tazlestobart		99.66%	Unkown
HY-P990722	Danvilostomig		98.38%	Unkown
HY-P991139	Futermestotug	Inhibitor	/	Unkown
HY-P99354	Bavunalimab		99.408%	Unkown
HY-P990848	Anti-CTLA-4/CD152 Antibody (BN13)	Inhibitor	/	Unkown
HY-P991566	KD6001	Inhibitor	/	Unkown
HY-P991951	ABA04		/	Unkown
HY-P991952	ADU-1604	Inhibitor	/	Unkown
HY-P991953	BAT4706		/	Unkown
HY-P991958	GIGA-564	Inhibitor	/	Unkown
HY-P991959	JMW-3B3	Inhibitor	/	Unkown
HY-P991960	JS007		/	Unkown
HY-P991961	REGN4659	Inhibitor	/	Unkown
HY-P992062	Anti-Mouse CD80 Antibody (TKMG48)	Agonist	/	Unkown
HY-P991775	Anti-Rat CTLA-4 Antibody (WKH203)	Inhibitor	/	Unkown
HY-P991827	Anti-Mouse CTLA-4 Antibody (UC10-4F10-11)	Inhibitor	/	Unkown

Species	Symbol	Source	ID
Homo sapiens	CTLA4	NCBI	NCBI:1493
Canis familiaris	CTLA4	NCBI	NCBI:403696
Macaca fascicularis	CTLA4	NCBI	NCBI:102115124
Mus musculus	CTLA4	NCBI	NCBI:12477
Rattus norvegicus	CTLA4	NCBI	NCBI:63835
Macaca mulatta	CTLA4	NCBI	NCBI:705673

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