2. Immunology/Inflammation
  3. CTLA-4
  4. Porustobart

Porustobart  (Synonyms: HBM-4003)

Cat. No.: HY-P990703 Purity: 99.70%
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Porustobart (HBM-4003) is a fully human anti-CTLA-4 heavy chain only antibody (HCAb). Porustobart can significantly improve the depletion of regulatory T cells (Treg cells) with high CTLA-4 expression in tumor tissues by enhancing ADCC activity. Porustobart can be used for tumor research.

For research use only. We do not sell to patients.

CAS No. : 2649372-91-6

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Description

Porustobart (HBM-4003) is a fully human anti-CTLA-4 heavy chain only antibody (HCAb). Porustobart can significantly improve the depletion of regulatory T cells (Treg cells) with high CTLA-4 expression in tumor tissues by enhancing ADCC activity. Porustobart can be used for tumor research[1].

Isotype

[G1 VH-h-CH2-CH3]-dimer
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

CTLA4
Clinical Trial
Gene ID

1493  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

77.928 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • (VH-CH2-CH3)3_S
Biological Activity
  • Immobilized CTLA-4 Protein, Human (HEK293, HY-P72959) can bind Porustobart. The EC50 for this effect is 4.161 ng/mL.
Purity & Documentation
References
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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Porustobart2649372-91-6HBM-4003HBM4003HBM 4003CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152Inhibitorinhibitorinhibit

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