Porustobart
Based on 1 Customer Validation
Porustobart (HBM-4003) is a fully human anti-CTLA-4 heavy chain only antibody (HCAb). Porustobart can significantly improve the depletion of regulatory T cells (Treg cells) with high CTLA-4 expression in tumor tissues by enhancing ADCC activity. Porustobart can be used for tumor research.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 2649372-91-6
- Molecular Weight:77.928 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
[G1 VH-h-CH2-CH3]-dimer
Human
CTLA4
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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(VH-CH2-CH3)3_S
ELISA, FACS, Functional assay
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Immobilized CTLA-4 Protein, Human (HEK293, HY-P72959) can bind Porustobart. The EC50 for this effect is 4.161 ng/mL.
Chemical Information
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CAS No. 2649372-91-6
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Appearance Liquid
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Molecular Weight 77.928 kDa
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Color Colorless to light yellow
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Synonyms
HBM-4003
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (253 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Porustobart
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)