Pik3cd - phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 366508

About Pik3cd

Primary_assembly 5: 160,094,952-160,120,930 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 16 phenotypes. Biased expression in Spleen (RPKM 363.9), Thymus (RPKM 286.5) and 9 other tissues.

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in negative regulation of gene expression. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cd Products (1)

mRNA Protein Name
NM_001108978.1 NP_001102448.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
28947594 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cd Protein Structure

PI3K_p85B

PI3K_p85B: pfam02192 (31 - 106)

PI3K_rbd

PI3K_rbd: pfam00794 (181 - 280)

C2_PI3K_class_I_beta_delta

C2_PI3K_class_I_beta_delta: cd08693 (313 - 480)

PI3Ka

PI3Ka: smart00145 (503 - 686)

PI3Kc_IA_delta

PI3Kc_IA_delta: cd05174 (678 - 1045)

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  • 1048 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

  • catalytic phosphatidylinositol 3-kinase delta

  • phosphatidylinositol 3-kinase catalytic delta polypeptide

  • phosphoinositide-3-kinase, catalytic, delta polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161366 OMS14 Inhibitor 99.09% Unkown
HY-RS02840 CLSTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10529 PIK3CD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10530 Pik3cd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10531 Pik3cd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3cd NCBI NCBI:5293