PIK3CD
p110δ, encoded by PIK3CD, is the hematopoietic-restricted catalytic subunit of class IA PI3K. It signals downstream of the B-cell receptor, co-receptors and cytokine receptors in leukocytes, producing PIP3 that engages AKT and its effectors to control lymphocyte activation, proliferation and migration. Because of this near-exclusive expression in blood cells, p110δ became a landmark immuno-oncology target: the selective inhibitor idelalisib demonstrated clinical benefit in B-cell malignancies, and further p110δ inhibitors are in development for lymphoma, leukemia and autoimmune disease. Germline gain-of-function mutations cause the immunodeficiency syndrome APDS. Its leukocyte-selective biology additionally positions p110δ in chronic inflammatory and allergic airway responses.
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PIK3CD Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
