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PA2G4 - proliferation-associated 2G4 Gene

Also Known as EBP1; HG4-1; p38-2G4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5036

About PA2G4

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,104,559-56,113,910 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 37.0), esophagus (RPKM 35.3) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and Other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human Cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

PA2G4 Products (1)

mRNA	Protein	Name
NM_006191.3	NP_006182.2	proliferation-associated protein 2G4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nucleic acid binding	IDA IDA: Inferred from direct assay	15073182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11268000	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	15073182	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19037095	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15073182	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16832058	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16832058	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15073182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PA2G4 Protein Structure

Peptidase_M24

0
100
200
300
394 a.a.

Protein Preferred Names	Protein Names
proliferation-associated protein 2G4	ErbB-3 binding protein 1

PA2G4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PA2G4	Q9UQ80	TMED7	Homo sapiens	Q9Y3B3	Anti Tag CoIP	33961781
Intra	PA2G4	Q9UQ80	TMED7	Homo sapiens	Q9Y3B3	Anti Tag CoIP	28514442
Intra	PA2G4	Q9UQ80	NCL	Homo sapiens	P19338	Anti Tag CoIP	15064750
Intra	PA2G4	Q9UQ80	SIN3A	Homo sapiens	Q96ST3	Pull Down	16254079
Intra	PA2G4	Q9UQ80	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	16254079
Intra	PA2G4	Q9UQ80	RB1	Homo sapiens	P06400	Pull Down	11268000
Intra	PA2G4	Q9UQ80	RB1	Homo sapiens	P06400	Anti Bait CoIP	11268000

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PA2G4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75726	EBP1 Protein, Human (His)	Q9UQ80-1 (S2-D394)	≥ 90%, as determined by reducing SDS-PAGE.

PA2G4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82764	EBP1 Antibody (YA2509)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09947	PA2G4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20461	Pa2g4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26970	Pa2g4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PA2G4	VGNC	VGNC:82495
Mus musculus	PA2G4	MGD	MGI:894684
Canis familiaris	PA2G4	VGNC	VGNC:82290
Rattus norvegicus	PA2G4	RGD	RGD:1302994
Bos taurus	PA2G4	VGNC	VGNC:82306