ATL1 - atlastin GTPase 1 Gene

Also Known as FSP1; GBP3; SPG3; HSN1D; SPG3A; AD-FSP; atlastin1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51062

About ATL1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:50,533,082-50,633,068 (from NCBI)

This gene has 23 transcripts (splice variants), 214 orthologues, 10 paralogues and is associated with 4 phenotypes. Broad expression in brain (RPKM 34.8), endometrium (RPKM 5.1) and 15 other tissues.

Summary

The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ATL1 Products (3)

mRNA	Protein	Name
NM_001127713.1	NP_001121185.1	atlastin-1 isoform b
NM_015915.5	NP_056999.2	atlastin-1 isoform a
NM_181598.4	NP_853629.2	atlastin-1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	14506257	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	14506257	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21220294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16815977	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endoplasmic reticulum organization	IDA IDA: Inferred from direct assay	19665976	GOA
involved in endoplasmic reticulum tubular network membrane organization	IMP IMP: Inferred from mutant phenotype	27619977	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	14506257	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19665976	GOA
located in endoplasmic reticulum tubular network membrane	IDA IDA: Inferred from direct assay	27619977	GOA
located in membrane	IDA IDA: Inferred from direct assay	14506257	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATL1 Protein Structure

GBP

0
100
200
300
400
500
558 a.a.

Protein Preferred Names	Protein Names
atlastin-1	GBP-3

ATL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATL1	Q8WXF7	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	ATL1	Q8WXF7	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	CISD2	Homo sapiens	Q8N5K1	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32814053
Intra	ATL1	Q8WXF7	YARS1	Homo sapiens	P54577	Y2H Array	32814053
Intra	ATL1	Q8WXF7	YARS1	Homo sapiens	P54577	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	YARS1	Homo sapiens	P54577	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ATL1	Q8WXF7	RAB7A	Homo sapiens	P51149	Y2H Array	32814053
Intra	ATL1	Q8WXF7	RAB7A	Homo sapiens	P51149	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	RAB7A	Homo sapiens	P51149	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	ATL1	Q8WXF7	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	PPT1	Homo sapiens	P50897	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	PPT1	Homo sapiens	P50897	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	PPT1	Homo sapiens	P50897	Y2H Array	32814053
Intra	ATL1	Q8WXF7	ehd27213144	Homo sapiens	EBI-25865403	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	Crosslink	21368113
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	X-Ray Diffraction	23334294
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	X-Ray Diffraction	21368113
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	FRET	23334294
Intra	ATL1	Q8WXF7	ccsb_9919	Homo sapiens	EBI-25847655	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	GMS	23334294
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	GMS	21368113
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	SLS	21220294
Intra	ATL1	Q8WXF7	ehd27213144	Homo sapiens	EBI-25865403	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	X-Ray Diffraction	21220294
Intra	ATL1	Q8WXF7	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Array	32814053
Intra	ATL1	Q8WXF7	ehd27213144	Homo sapiens	EBI-25865403	Y2H Array	32814053
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	GMS	21220294
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	SAXS	21220294
Intra	ATL1	Q8WXF7	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	ATL1	Homo sapiens	Q8WXF7	Solution Sedimentation	21368113
Intra	ATL1	Q8WXF7	PEX7	Homo sapiens	O00628-2	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	PEX7	Homo sapiens	O00628-2	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	PEX7	Homo sapiens	O00628-2	Y2H Array	32814053
Intra	ATL1	Q8WXF7	PANK2	Homo sapiens	Q9BZ23-2	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	PANK2	Homo sapiens	Q9BZ23-2	Y2H Array	32814053
Intra	ATL1	Q8WXF7	PANK2	Homo sapiens	Q9BZ23-2	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	ZFYVE27	Homo sapiens	Q5T4F4	Anti Tag CoIP	23969831
Intra	ATL1	Q8WXF7	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	ATL1	Q8WXF7	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ATL1	Q8WXF7	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	ATL1	Q8WXF7	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ATL1	Q8WXF7	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	ATL1	Q8WXF7	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	ATL1	Q8WXF7	PRNP	Homo sapiens	P04156	Y2H Array	32814053
Intra	ATL1	Q8WXF7	PRNP	Homo sapiens	P04156	Validated Y2H	32814053
Intra	ATL1	Q8WXF7	PRNP	Homo sapiens	P04156	Y2H Pooling	32814053
Cross	ATL1	Q8WXF7	Rtn4	Rattus norvegicus	Q9JK11-3	Anti Tag CoIP	19665976

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77214	SPG3A/ATL1 Protein, Human (sf9, His)	Q8WXF7-1 (M1-T447)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Spastic Paraplegia 3, Autosomal Dominant	SPG3A Strumpell Disease Hereditary Spastic Paraplegia 3a SPG3 Fsp1 Autosomal Dominant Spastic Paraplegia Type 3 Familial Spastic Paraplegia, Autosomal Dominant, 1 Spastic Paraplegia 3a, Autosomal Dominant Autosomal Dominant Familial Spastic Paraplegia 1 Autosomal Dominant Spastic Paraplegia 3 Spastic Paraplegia 3 Familial Spastic Paraplegia Autosomal Dominant 1 Strumpell-Lorrain Syndrome Paraplegia, Spastic, Autosomal Dominant, Type 3a Spastic Paraplegia, Hereditary
Neuropathy, Hereditary Sensory, Type Id	HSN1D Hereditary Sensory Neuropathy Type 1d Neuropathy, Hereditary Sensory, Type 1d Neuropathy, Hereditary Sensory, 1d Hereditary Sensory Neuropathy Type Id Neuropathy, Sensory, Hereditary, Type Id
Spastic Paraplegia 3a	Spg3a Atl1-Hsp Spastic Paraplegia Type 3a Spastic Paraplegia 3 Spastic Paraplegia 3, Autosomal Dominant
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Hereditary Sensory And Autonomic Neuropathy Type 1	Hereditary Sensory And Autonomic Neuropathy Type I Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome Hsan1e Hsan1 Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy Hsn1e Hsnie Hereditary Sensory Neuropathy Type Ie Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome Hereditary Sensory And Autonomic Neuropathy Type Ie Hereditary Sensory And Autonomic Neuropathy Type 1e Hereditary Sensory Neuropathy With Hearing Loss And Dementia Dnmt1-Complex Disorder Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss Hsn Ie Hereditary Sensory Autonomic Neuropathy, Type 1 Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Paraplegia	Paraplegia, Lower Severe Or Complete Loss Of Motor Function In The Lower Extremities And Lower Portions Of The Trunk
Spastic Paraplegia 73, Autosomal Dominant	SPG73 Hereditary Spastic Paraplegia 73 Autosomal Dominant Spastic Paraplegia Type 73 Autosomal Dominant Spastic Paraplegia 73 Paraplegia, Spastic, Autosomal Dominant, Type 73
Masa Syndrome	L1 Syndrome Crash Syndrome X-Linked Hydrocephalus Syndrome SPG1 Gareis-Mason Syndrome Spastic Paraplegia 1, X-Linked Corpus Callosum Hypoplasia-Retardation-Adducted Thumbs-Spasticity-Hydrocephalus Syndrome L1cam Syndrome Spastic Paraplegia 1 Mental Retardation, Aphasia, Shuffling Gait, And Adducted Thumbs Clasped Thumb And Mental Retardation Thumb, Congenital Clasped, With Mental Retardation Adducted Thumb With Mental Retardation Hereditary Spastic Paraplegia 1 X-Linked Complicated Hereditary Spastic Paraplegia Type 1 X-Linked Corpus Callosum Agenesis X-Linked Spastic Paraplegia 1 L1 Disease X-Linked Intellectual Disability - Corpus Callosum Agenesis - Spastic Quadriparesis Adducted Thumb With Intellectual Disability Clasped Thumb And Intellectual Disability Intellectual Disability Aphasia Shuffling Gait Adducted Thumbs Thumb Congenital Clasped With Intellectual Disability X-Linked Intellectual Disability-Corpus Callosum Agenesis-Spastic Quadriparesis Syndrome Adducted Thumbs-Mental Retardation Syndrome Corpus Callosum Hypoplasia, Mental Retardation, Adducted Thumbs, Spastic Paraplegia, Hydrocephalus Syndrome Mental Retardation-Clasped Thumb Syndrome Intellectual Disability-Aphasia-Shuffling Gait-Adducted Thumbs Syndrome Spastic Paraplegia Type 1, X-Linked MASA Corpus Callosum Hypoplasia-Psychomotor Retardation, Adducted Thumbs-Spastic Paraparesis-Hydrocephalus Crash Masa Syndrome
Spastic Paraplegia 2, X-Linked	SPG2 Hereditary Spastic Paraplegia 2 Sppx2 Spastic Paraplegia Type 2 Spastic Paraplegia 2 Hereditary X-Linked Recessive Spastic Paraplegia X-Linked Spastic Paraplegia 2 X Linked Recessive Hereditary Spastic Paraplegia Spastic Gait Type 2 Spastic Paraparesis Type 2 X-Linked Spastic Paraplegia Type 2 Spastic Paraplegia Type 2, X-Linked Spastic Paraplegia-2 Paraplegia, Spastic, Type 2
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Spastic Paraplegia 12, Autosomal Dominant	SPG12 Hereditary Spastic Paraplegia 12 Autosomal Dominant Spastic Paraplegia Type 12 Autosomal Dominant Spastic Paraplegia 12 Spastic Paraplegia 12 Spastic Paraplegia-12 Paraplegia, Spastic, Autosomal Dominant, Type 12
Spastic Paraplegia 6, Autosomal Dominant	SPG6 Fsp3 Hereditary Spastic Paraplegia 6 Autosomal Dominant Spastic Paraplegia Type 6 Spastic Paraplegia 6 Familial Spastic Paraplegia Autosomal Dominant 3 Familial Spastic Paraplegia, Autosomal Dominant, 3 Autosomal Dominant Familial Spastic Paraplegia Type 3 Autosomal Dominant Spastic Paraplegia 6 Spastic Paraplegia-6 Paraplegia, Spastic, Type 6
Spastic Paraplegia 13, Autosomal Dominant	SPG13 Hereditary Spastic Paraplegia 13 Autosomal Dominant Spastic Paraplegia 13 Spastic Paraplegia 13 Autosomal Dominant Spastic Paraplegia Type 13 Spastic Paraplegia-13 Paraplegia, Spastic, Type 13
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Spastic Paraplegia 14, Autosomal Recessive	SPG14 Hereditary Spastic Paraplegia 14 Autosomal Recessive Spastic Paraplegia Type 14 Autosomal Recessive Spastic Paraplegia 14 Spastic Paraplegia 14
Spastic Paraplegia 61, Autosomal Recessive	SPG61 Hereditary Spastic Paraplegia 61 Autosomal Recessive Spastic Paraplegia Type 61 Autosomal Recessive Spastic Paraplegia 61 Paraplegia, Spastic, Type 61, Autosomal Recessive
Spastic Paraplegia 42, Autosomal Dominant	SPG42 Hereditary Spastic Paraplegia 42 Autosomal Dominant Spastic Paraplegia Type 42 Autosomal Dominant Spastic Paraplegia 42 Paraplegia, Spastic, Type 42, Autosomal Dominant
Spastic Paraplegia 20, Autosomal Recessive	Troyer Syndrome SPG20 Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting Spastic Paraplegia, Autosomal Recessive, Troyer Type Autosomal Recessive Spastic Paraplegia Type 20 Autosomal Recessive Hereditary Spastic Paraplegia Spastic Paraplegia 20 Cross-Mckusick Syndrome Autosomal Recessive Spastic Paraplegia 20 Autosomal Recessive Spastic Paraplegia Troyer Type Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting Hereditary Spastic Paraplegia 20 Spastic Paraplegia Type 20 Hereditary Spastic Paraplegia Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting Spastic Paraplegia Autosomal Recessive Troyer Type Trs Spastic Paraplegia Hereditary Autosomal Recessive Spastic Paraplegia, Hereditary
Spastic Paraplegia 43, Autosomal Recessive	SPG43 Hereditary Spastic Paraplegia 43 Autosomal Recessive Spastic Paraplegia Type 43 Autosomal Recessive Spastic Paraplegia 43 Paraplegia, Spastic, Type 43, Autosomal Recessive
Retinitis Pigmentosa 3	RP3 Retinitis Pigmentosa 15 Rp15 Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women Cone-Rod Degeneration, X-Linked Retinitis Pigmentosa Type 15 X-Linked Cone-Rod Degeneration X-Linked Retinitis Pigmentosa 3 Xlrp3 Xlrp-3 Retinitis Pigmentosa-3 Retinitis Pigmentosa, Type 3
Neuropathy	Peripheral Neuropathy Peripheral Neuropathies
Hereditary Spastic Paraplegia 30	Autosomal Spastic Paraplegia Type 30 Spg30 Autosomal Recessive Spastic Paraplegia 30
Neuronopathy, Distal Hereditary Motor, Type Va	Dsmav Distal Hereditary Motor Neuropathy Type V Young Adult-Onset Distal Hereditary Motor Neuropathy Neuronopathy, Distal Hereditary Motor, Type V Distal Hereditary Motor Neuronopathy Type 5 Dhmn5 Distal Spinal Muscular Atrophy Type 5 HMN5A Hmn5 Dhmn5a Dhmn Va Dsmava Spinal Muscular Atrophy, Distal, With Upper Limb Predominance Distal Hmn V Autosomal Recessive Distal Spinal Muscular Atrophy Type 5 Dsma5 Young Adult-Onset Dhmn Dhmn-V Hmn V Neuronopathy, Distal Hereditary Motor, Type 5a Hmn 5a Neuropathy, Distal Hereditary Motor, Type Va Spinal Muscular Atrophy, Distal, Type Va Spinal Muscular Atrophy, Distal, Type V Distal Spinal Muscular Atrophy Type V Distal Spinal Muscular Atrophy With Upper Limb Predominance Distal Hereditary Motor Neuronopathy Type 5a Distal Hmn Va Distal Spinal Muscular Atrophy Type Va Distal Hereditary Motor Neuropathy, Type V Distal Hereditary Motor Neuronopathy, Type V Distal Spinal Muscular Atrophy, Type V Spinal Muscular Atrophy, Distal Type V Distal Hereditary Motor Neuropathy Type 5 Neuronopathy, Distal Hereditary Motor, 5a Dhmn V Distal Hereditary Motor Neuronopathy Type Va Distal Hereditary Motor Neuropathy Type Va Dsma-V Hmn Va Spinal Muscular Atrophy Distal Type V Spinal Muscular Atrophy Distal Type Va Spinal Muscular Atrophy Distal With Upper Limb Predominance Neuropathy, Distal Hereditary Motor, Type V Neuropathy, Motor, Distal, Hereditary, Type Va
Spastic Paraplegia 57, Autosomal Recessive	SPG57 Hereditary Spastic Paraplegia 57 Autosomal Recessive Spastic Paraplegia Type 57 Autosomal Recessive Spastic Paraplegia 57 Spastic Paraplegia Due To Partial Tfg Deficiency Paraplegia, Spastic, Type 57, Autosomal Recessive
Spastic Paraplegia 31, Autosomal Dominant	SPG31 Hereditary Spastic Paraplegia 31 Spastic Paraplegia 31 Autosomal Dominant Spastic Paraplegia 31 Autosomal Dominant Spastic Paraplegia Type 31 Spastic Paraplegia Type 31 Paraplegia, Spastic, Autosomal Dominant, Type 31
Spastic Paraplegia 10, Autosomal Dominant	SPG10 Hereditary Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Type 10 Spastic Paraplegia 10 Spastic Paraplegia 10 With Or Without Peripheral Neuropathy Autosomal Dominant Spastic Paraplegia 10 Autosomal Dominant Spastic Paraplegia Spastic Paraplegia, Autosomal Dominant Paraplegia, Spastic, Autosomal Dominant, Type 10
Spastic Paraplegia 36, Autosomal Dominant	SPG36 Hereditary Spastic Paraplegia 36 Autosomal Dominant Spastic Paraplegia Type 36 Autosomal Dominant Spastic Paraplegia 36
Spastic Paraplegia 18, Autosomal Recessive	SPG18 Idmdc Hereditary Spastic Paraplegia 18 Intellectual Disability, Motor Dysfunction, And Joint Contractures Autosomal Recessive Spastic Paraplegia Type 18 Autosomal Recessive Spastic Paraplegia 18 Intellectual Disability, Motor Dysfunction And Joint Contractures Spastic Paraplegia 18 Intellectual Disability Motor Dysfunction And Joint Contractures Paraplegia, Spastic, Type 18
Hereditary Spastic Paraplegia 49	Autosomal Recessive Spastic Paraplegia Type 49 Autosomal Recessive Spastic Paraplegia 49 Spg49 Paraplegia, Spastic, Type 49, Autosomal Recessive
Hereditary Sensory Neuropathy	Hereditary Sensory And Autonomic Neuropathy Hereditary Sensory And Autonomic Neuropathies Familial Dysautonomia, Type Ii Hsan Sensory Neuropathy Hereditary Neuropathy, Sensory And Autonomic, Hereditary Neuropathy, Sensory, Hereditary Sensory Neuropathy, Hereditary Charcot-Marie-Tooth Disease Cmt - [Charcot-Marie-Tooth Disease]
Spastic Paraplegia 54, Autosomal Recessive	SPG54 Hereditary Spastic Paraplegia 54 Autosomal Recessive Spastic Paraplegia Type 54 Autosomal Recessive Spastic Paraplegia 54 Paraplegia, Spastic, Type 54, Autosomal Recessive
Spastic Paraplegia 24, Autosomal Recessive	SPG24 Spastic Paraplegia 24 Hereditary Spastic Paraplegia 24 Autosomal Recessive Spastic Paraplegia Type 24 Autosomal Recessive Spastic Paraplegia 24
Spastic Paraplegia 53, Autosomal Recessive	SPG53 Hereditary Spastic Paraplegia 53 Autosomal Recessive Spastic Paraplegia Type 53 Autosomal Recessive Spastic Paraplegia 53 Paraplegia, Spastic, Type 53, Autosomal Recessive
Spastic Paraplegia 4, Autosomal Dominant	SPG4 Hereditary Spastic Paraplegia 4 Fsp2 Autosomal Dominant Spastic Paraplegia Type 4 Familial Spastic Paraplegia, Autosomal Dominant, 2 Autosomal Dominant Spastic Paraplegia 4 Familial Spastic Paraplegia Autosomal Dominant 2 Paraplegia, Spastic, Autosomal Dominant, Type 4
Spastic Paraplegia 62, Autosomal Recessive	SPG62 Hereditary Spastic Paraplegia 62 Autosomal Recessive Spastic Paraplegia Type 62 Spastic Paraplegia 62 Autosomal Recessive Spastic Paraplegia 62 Paraplegia, Spastic, Type 62
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Hereditary Spastic Paraplegia 35	Autosomal Recessive Spastic Paraplegia Type 35 Spg35 Autosomal Recessive Spastic Paraplegia 35 Fahn Fatty Acid Hydroxylase-Associated Neurodegeneration Leukodystrophy, Dysmyelinating And Spastic Paraparesis With Or Without Dystonia
Spastic Paraplegia, Optic Atrophy, And Neuropathy	Spoan Syndrome SPOAN Spastic Paraplegia, Optic Atropy, And Neuropathy Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Spastic Paraplegia 8, Autosomal Dominant	SPG8 Hereditary Spastic Paraplegia 8 Autosomal Dominant Spastic Paraplegia Type 8 Autosomal Dominant Spastic Paraplegia 8 Paraplegia, Spastic, Autosomal Dominant, Type 8
Spastic Paraplegia 34, X-Linked	SPG34 Hereditary Spastic Paraplegia 34 X-Linked Spastic Paraplegia Type 34 X-Linked Spastic Paraplegia 34
Spastic Paraplegia 17, Autosomal Dominant	Silver Syndrome SPG17 Silver Spastic Paraplegia Syndrome Spastic Paraplegia With Amyotrophy Of Hands And Feet Hereditary Spastic Paraplegia 17 Autosomal Dominant Spastic Paraplegia Type 17 Spastic Paraplegia 17 Spastic Paraplegia-Amyotrophy Of Hands And Feet Autosomal Dominant Spastic Paraplegia 17 Dhmn5b Distal Hereditary Motor Neuropathy Type 5b Paraplegia, Spastic, Autosomal Dominant, Type 17 Russell-Silver Syndrome Neuronopathy, Distal Hereditary Motor, Type Vb
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Spastic Cerebral Palsy	Palsy, Cerebral, Spastic Infantile Hemiplegia Nos Postnatal Infantile Hemiplegia Nos Congenital Spastic Hemiplegia Spastic Hemiplegic Cerebral Palsy Congenital Hemiplegia Nos Hemiplegic Cerebral Palsy Hemiplegic Infantile Cerebral Palsy
Spastic Ataxia	Spax Ataxia, Spastic
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01157	ATL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01414	BCL11B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19876	Atl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26375	Atl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATL1	VGNC	VGNC:38230
Macaca mulatta	ATL1	VGNC	VGNC:70049
Felis catus	ATL1	VGNC	VGNC:60008
Rattus norvegicus	ATL1	RGD	RGD:1359232
Bos taurus	ATL1	VGNC	VGNC:26265
Mus musculus	ATL1	MGD	MGI:1921241
Others	ATL1	NCBI