TMX2 - thioredoxin related transmembrane protein 2 Gene

Also Known as PIG26; CGI-31; PDIA12; NEDMCMS; TXNDC14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51075

About TMX2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,712,593-57,740,973 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 42.0), thyroid (RPKM 36.4) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]

TMX2 Products (10)

mRNA Protein Name
NM_001144012.3 NP_001137484.1 thioredoxin-related transmembrane protein 2 isoform 2
NM_001347890.2 NP_001334819.1 thioredoxin-related transmembrane protein 2 isoform 4
NM_001347891.2 NP_001334820.1 thioredoxin-related transmembrane protein 2 isoform 5
NM_001347892.2 NP_001334821.1 thioredoxin-related transmembrane protein 2 isoform 6
NM_001347893.2 NP_001334822.1 thioredoxin-related transmembrane protein 2 isoform 7
NM_001347894.2 NP_001334823.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347895.2 NP_001334824.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347896.2 NP_001334825.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347898.2 NP_001334827.1 thioredoxin-related transmembrane protein 2 isoform 8
NM_015959.4 NP_057043.1 thioredoxin-related transmembrane protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disulfide oxidoreductase activity IDA
IDA: Inferred from direct assay
31735293 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31735293 GOA
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
31735293 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
31735293 GOA
is active in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
22045338 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: Inferred from direct assay
31735293 GOA
located in mitochondrion IMP
IMP: Inferred from mutant phenotype
31735293 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMX2 Protein Structure

Thioredoxin

Thioredoxin: Thioredoxin (140 - 230)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

thioredoxin-related transmembrane protein 2

  • cell proliferation-inducing gene 26 protein

TMX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMX2 Q9Y320 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
TMX2 Q9Y320 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
Intra
TMX2 Q9Y320 FAM241B Homo sapiens Q96D05-2
Y2H Array
32296183
Intra
TMX2 Q9Y320 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
Intra
TMX2 Q9Y320 TMEM71 Homo sapiens Q6P5X7-2
Y2H Array
32296183
Intra
TMX2 Q9Y320 TMEM71 Homo sapiens Q6P5X7-2
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 RNF24 Homo sapiens Q9Y225-2
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMX2 Q9Y320 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
TMX2 Q9Y320 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
TMX2 Q9Y320 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
TMX2 Q9Y320 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
TMX2 Q9Y320 STATH Homo sapiens P02808
Y2H Array
32296183
Intra
TMX2 Q9Y320 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
TMX2 Q9Y320 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
TMX2 Q9Y320 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Intra
TMX2 Q9Y320 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
TMX2 Q9Y320 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra
TMX2 Q9Y320 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra
TMX2 Q9Y320 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMX2 Proteins

Cat. No. Product Name Accession Purity
HY-P71371 TMX2 Protein, Human (His) Q9Y320-1 (M125-K296) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Cortical Malformations, And Spasticity

  • NEDMCMS

  • Vandervore-Schot Syndrome
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Polymicrogyria

  • Pmg
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14780 TMX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19964 Tmx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26466 Tmx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMX2 MGD MGI:1914208
Canis familiaris TMX2 VGNC VGNC:52054
Rattus norvegicus TMX2 RGD RGD:1359456
Felis catus TMX2 VGNC VGNC:81104
Bos taurus TMX2 VGNC VGNC:54897
Others TMX2 NCBI