Syt6 - synaptotagmin VI Gene

Also Known as sytVI; 3110037A08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54524

Summary

Enables calcium-dependent protein binding activity; phospholipid binding activity; and protein dimerization activity. Involved in acrosome reaction. Located in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is extrinsic component of membrane and integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SYT6 (synaptotagmin 6). [provided by Alliance of Genome Resources, Apr 2022]

Syt6 Products (6)

mRNA Protein Name
NM_001276676.2 NP_001263605.1 synaptotagmin-6 isoform 2
NM_001276677.2 NP_001263606.1 synaptotagmin-6 isoform 3
NM_001276679.1 NP_001263608.1 synaptotagmin-6 isoform 3
NM_001276680.1 NP_001263609.1 synaptotagmin-6 isoform 4
NM_001276681.1 NP_001263610.1 synaptotagmin-6 isoform 3
NM_018800.5 NP_061270.2 synaptotagmin-6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
8626542 MGI
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
15774481 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
10531343 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
12860971 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10531343 MGI
NOT enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
10531344 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
10531344 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10531343 MGI
NOT enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10531344 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
10531344 MGI
Biological Process GO Annotation Evidence References Source
involved in acrosome reaction IDA
IDA: Inferred from direct assay
15774481 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10531344 MGI
located in cytosol IDA
IDA: Inferred from direct assay
10531344 MGI
located in membrane IDA
IDA: Inferred from direct assay
10531344 MGI
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
10531344 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-6

Syt6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Syt6 Q9R0N8 Syt3 Mus musculus O35681
Comigration in SDS
10531343
Intra
Syt6 Q9R0N8 Syt9 Mus musculus Q9R0N9
Comigration in SDS
10531343
Intra
Syt6 Q9R0N8 Syt10 Mus musculus Q9R0N4
Comigration in SDS
10531343
Intra
Syt6 Q9R0N8 Syt6 Mus musculus Q9R0N8
Comigration in SDS
10531343
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14118 SYT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20343 Syt6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26851 Syt6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt6 NCBI NCBI:148281