SYT6 - synaptotagmin 6 Gene

Homo sapiens

Also known as sytVI

Gene ID: 148281 | Gene type: protein coding

About SYT6

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,089,292-114,153,869 (from NCBI)

This gene has 10 transcripts (splice variants), 229 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.6), kidney (RPKM 0.8) and 6 other tissues.

Summary

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

SYT6 Products(7)

mRNA	Protein	Name
NM_001253772.2	NP_001240701.1	synaptotagmin-6 isoform a
NM_001270805.2	NP_001257734.1	synaptotagmin-6 isoform b
NM_001366223.1	NP_001353152.1	synaptotagmin-6 isoform b
NM_001366224.1	NP_001353153.1	synaptotagmin-6 isoform c
NM_001366225.1	NP_001353154.1	synaptotagmin-6 isoform d
NM_001366226.1	NP_001353155.1	synaptotagmin-6 isoform e
NM_205848.4	NP_995320.1	synaptotagmin-6 isoform b

SYT6 Protein Structure

0
100
200
300
400
510 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-6

synaptotagmin VI

Recombinant SYT6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74533	Synaptotagmin VI Protein, Human (His)	NP_995320 (V359-L510)	≥95%

Related Diseases

Diseases

Alias

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

Lgmd2b	Lgmd3
Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency	Limb-Girdle Muscular Dystrophy Type 3
Muscular Dystrophy, Limb-Girdle, Type 2b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14118	SYT6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SYT6	VGNC	VGNC:65901
Rattus norvegicus	SYT6	RGD	RGD:62012
Bos taurus	SYT6	VGNC	VGNC:55685
Macaca mulatta	SYT6	VGNC	VGNC:78162
Mus musculus	SYT6	MGD	MGI:1859544
Canis familiaris	SYT6	VGNC	VGNC:47049
Others	SYT6	NCBI