SYT6 - synaptotagmin 6 Gene

Also Known as sytVI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148281

About SYT6

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,089,292-114,153,869 (from NCBI)

This gene has 10 transcripts (splice variants), 229 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.6), kidney (RPKM 0.8) and 6 other tissues.

Summary

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

SYT6 Products (7)

mRNA Protein Name
NM_001253772.2 NP_001240701.1 synaptotagmin-6 isoform a
NM_001270805.2 NP_001257734.1 synaptotagmin-6 isoform b
NM_001366223.1 NP_001353152.1 synaptotagmin-6 isoform b
NM_001366224.1 NP_001353153.1 synaptotagmin-6 isoform c
NM_001366225.1 NP_001353154.1 synaptotagmin-6 isoform d
NM_001366226.1 NP_001353155.1 synaptotagmin-6 isoform e
NM_205848.4 NP_995320.1 synaptotagmin-6 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7791877 GOA
enables clathrin binding IDA
IDA: Inferred from direct assay
7791877 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables syntaxin binding IDA
IDA: Inferred from direct assay
7791877 GOA
Biological Process GO Annotation Evidence References Source
involved in acrosomal vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
11437455 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT6 Protein Structure

C2

C2: C2 domain (246 - 331)

C2

C2: C2 domain (378 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 510 a.a.
Protein Preferred Names Protein Names

synaptotagmin-6

  • synaptotagmin VI

Related Diseases

Diseases Alias
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

  • Lgmd2b

  • Lgmd3

  • Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

  • Limb-Girdle Muscular Dystrophy Type 3

  • Muscular Dystrophy, Limb-Girdle, Type 2b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14118 SYT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20343 Syt6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26851 Syt6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SYT6 VGNC VGNC:65901
Rattus norvegicus SYT6 RGD RGD:62012
Bos taurus SYT6 VGNC VGNC:55685
Macaca mulatta SYT6 VGNC VGNC:78162
Mus musculus SYT6 MGD MGI:1859544
Canis familiaris SYT6 VGNC VGNC:47049
Others SYT6 NCBI