Icmt - isoprenylcysteine carboxyl methyltransferase Gene

Also Known as PPMT; STE14; pcCMT; HSTE14; Gm13095; 1700008E11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57295

Summary

Enables cAMP response element binding protein binding activity and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Acts upstream of or within several processes, including TOR signaling; bone mineralization; and determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Icmt Products (1)

mRNA Protein Name
NM_133788.2 NP_598549.1 protein-S-isoprenylcysteine O-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cAMP response element binding protein binding IMP
IMP: Inferred from mutant phenotype
14966563 MGI
enables protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
10747846 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within C-terminal protein methylation IMP
IMP: Inferred from mutant phenotype
10747846 MGI
involved in CAAX-box protein maturation IMP
IMP: Inferred from mutant phenotype
10747846 MGI
acts upstream of or within TOR signaling IMP
IMP: Inferred from mutant phenotype
23686339 MGI
acts upstream of or within bone mineralization IGI
IGI: Inferred from genetic interaction
23686339 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
23686339 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
14966563 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
11121396 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
12105862 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
23686339 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
11121396 MGI
acts upstream of or within neuromuscular process IGI
IGI: Inferred from genetic interaction
23686339 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
14966563 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
10747846 MGI
acts upstream of or within protein methylation IMP
IMP: Inferred from mutant phenotype
11121396 MGI
acts upstream of or within regulation of Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
14966563 MGI
acts upstream of or within regulation of cellular senescence IGI
IGI: Inferred from genetic interaction
23686339 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
23686339 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-S-isoprenylcysteine O-methyltransferase

  • prenylated protein carboxyl methyltransferase

  • prenylcysteine carboxyl methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (67)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16160 Cysmethynil 99.87% Unkown
HY-156500 ICMT-IN-1 Inhibitor 98.43% Unkown
HY-118563 Farnesylthioacetic acid Inhibitor 90.0% Unkown
HY-149708 UCM-13207 Inhibitor 99.61% Unkown
HY-155433 ICMT-IN-30 Inhibitor / Unkown
HY-157110 ICMT-IN-42 Inhibitor / Unkown
HY-155430 ICMT-IN-27 Inhibitor / Unkown
HY-149729 ICMT-IN-53 Inhibitor / Unkown
HY-157119 ICMT-IN-51 Inhibitor / Unkown
HY-149706 ICMT-IN-12 Inhibitor / Unkown
HY-155432 ICMT-IN-29 Inhibitor / Unkown
HY-155426 ICMT-IN-19 Inhibitor / Unkown
HY-155428 ICMT-IN-22 Inhibitor / Unkown
HY-157114 ICMT-IN-46 Inhibitor / Unkown
HY-157097 ICMT-IN-10 Inhibitor / Unkown
HY-149709 ICMT-IN-35 Inhibitor / Unkown
HY-157092B (R)-ICMT-IN-3 Inhibitor / Unkown
HY-157108 ICMT-IN-40 Inhibitor / Unkown
HY-155419 ICMT-IN-5 Inhibitor / Unkown
HY-155424 ICMT-IN-15 Inhibitor / Unkown
HY-157100 ICMT-IN-23 Inhibitor / Unkown
HY-149730 ICMT-IN-54 Inhibitor / Unkown
HY-155418 ICMT-IN-2 Inhibitor / Unkown
HY-157092 ICMT-IN-3 Inhibitor / Unkown
HY-155427 ICMT-IN-20 Inhibitor / Unkown
HY-157118 ICMT-IN-50 Inhibitor / Unkown
HY-157107 ICMT-IN-39 Inhibitor / Unkown
HY-157092A (S)-ICMT-IN-3 Inhibitor / Unkown
HY-157109 ICMT-IN-41 Inhibitor / Unkown
HY-157116 ICMT-IN-48 Inhibitor / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-157096 ICMT-IN-8 Inhibitor / Unkown
HY-157106 ICMT-IN-38 Inhibitor / Unkown
HY-157117 ICMT-IN-49 Inhibitor / Unkown
HY-157105 ICMT-IN-37 Inhibitor / Unkown
HY-157098 ICMT-IN-16 Inhibitor / Unkown
HY-157101 ICMT-IN-25 Inhibitor / Unkown
HY-157103 ICMT-IN-34 Inhibitor / Unkown
HY-155436 ICMT-IN-33 Inhibitor / Unkown
HY-157104 ICMT-IN-36 Inhibitor / Unkown
HY-155421 ICMT-IN-11 Inhibitor / Unkown
HY-157115 ICMT-IN-47 Inhibitor / Unkown
HY-155422 ICMT-IN-13 Inhibitor / Unkown
HY-157102 ICMT-IN-26 Inhibitor / Unkown
HY-157099 ICMT-IN-18 Inhibitor / Unkown
HY-155423 ICMT-IN-14 Inhibitor / Unkown
HY-157120 ICMT-IN-52 Inhibitor / Unkown
HY-157094 ICMT-IN-4 Inhibitor / Unkown
HY-157112 ICMT-IN-44 Inhibitor / Unkown
HY-155429 ICMT-IN-24 Inhibitor / Unkown
HY-155425 ICMT-IN-17 Inhibitor / Unkown
HY-155435 ICMT-IN-32 Inhibitor / Unkown
HY-157113 ICMT-IN-45 Inhibitor / Unkown
HY-155431 ICMT-IN-28 Inhibitor / Unkown
HY-155420 ICMT-IN-9 Inhibitor / Unkown
HY-155434 ICMT-IN-31 Inhibitor / Unkown
HY-157095 ICMT-IN-6 Inhibitor / Unkown
HY-149707 ICMT-IN-21 Inhibitor / Unkown
HY-157111 ICMT-IN-43 Inhibitor / Unkown
HY-149715 R1-11 Inhibitor / Unkown
HY-117776 CAY10677 Inhibitor / Unkown
HY-149710 POP-3MB Inhibitor / Unkown
HY-149712 Spermatinamine Inhibitor / Unkown
HY-149714 J6-3 Inhibitor / Unkown
HY-149711 Farnesylcysteine Inhibitor 99.29% Unkown
HY-149713 J1-1 Inhibitor / Unkown
HY-157206 ICMT-IN-55 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Icmt NCBI NCBI:23463