Akr1a1 - aldo-keto reductase family 1, member A1 (aldehyde reductase) Gene

Also Known as Akr1a4; 2610201A18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58810

Summary

Enables L-glucuronate reductase activity; alditol:NADP+ 1-oxidoreductase activity; and glucuronolactone reductase activity. Involved in cellular detoxification of aldehyde. Acts upstream of or within D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and aldehyde catabolic process. Located in apical plasma membrane and cytosol. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Akr1a1 Products (1)

mRNA Protein Name
NM_021473.3 NP_067448.1 aldo-keto reductase family 1 member A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
15769935 MGI
enables L-glucuronate reductase activity IMP
IMP: Inferred from mutant phenotype
20410296 MGI
enables S-nitrosoglutathione reductase (NADH) activity IMP
IMP: Inferred from mutant phenotype
31649033 MGI
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
14667815 MGI
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
22820017 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within D-glucuronate catabolic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in D-glucuronate catabolic process to D-xylulose 5-phosphate IDA
IDA: Inferred from direct assay
38160 MGI
acts upstream of or within L-ascorbic acid biosynthetic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
20410296 MGI
acts upstream of or within aldehyde catabolic process IDA
IDA: Inferred from direct assay
15769935 MGI
involved in cellular detoxification of aldehyde IMP
IMP: Inferred from mutant phenotype
22820017 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15769935 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
38160 MGI
located in cytosol IDA
IDA: Inferred from direct assay
15769935 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16635246 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16635246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

  • alcohol dehydrogenase

  • aldehyde reductase

  • aldo-keto reductase family 1, member A4 (aldehyde reductase)

  • glucuronate reductase

  • glucuronolactone reductase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
HY-156701 BAY-1128688 / Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 98.35% Unkown
HY-133708 β-Glucogallin 99.82% Unkown
HY-113114 Tetrahydrocortisone Substrate 99.97% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.87% Unkown
HY-D1341 Coumberone 99.73% Unkown
HY-N0310 Soyasaponin Bb 99.88% Unkown
HY-N8549A 5-Dihydrocortisone 99.83% Unkown
HY-N0412 Sesamoside Inhibitor 99.77% Unkown
HY-N2282 Zingiberen newsaponin 99.68% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177415 JSD26 Inhibitor 98.32% Unkown
HY-131586 3,7-Dihydroxyflavone 98.04% Unkown
HY-W069545 (S)-1-Tetralol 99.75% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-175331 ALR2-IN-7 Inhibitor 99.94% Unkown
HY-175639 ALR2-IN-8 Inhibitor / Unkown
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / Unkown
HY-181542 SG-55 / Unkown
HY-184928 S34-1040 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124432 CRT0093964 Inhibitor / Unkown
HY-RS17921 Akr1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24390 Akr1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1a1 NCBI NCBI:10327