AKR1A1 - aldo-keto reductase family 1 member A1 Gene

Also Known as ALR; ARM; DD3; ALDR1; HEL-S-6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10327

About AKR1A1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,550,826-45,570,049 (from NCBI)

This gene has 14 transcripts (splice variants), 234 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 113.8), duodenum (RPKM 66.6) and 25 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]

AKR1A1 Products (4)

mRNA Protein Name
NM_001202413.2 NP_001189342.1 aldo-keto reductase family 1 member A1
NM_001202414.2 NP_001189343.1 aldo-keto reductase family 1 member A1
NM_006066.4 NP_006057.1 aldo-keto reductase family 1 member A1
NM_153326.3 NP_697021.1 aldo-keto reductase family 1 member A1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-glucuronate reductase activity EXP
EXP: Inferred from Experiment
7669785 GOA
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
10510318 GOA
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
10510318 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in daunorubicin metabolic process IDA
IDA: Inferred from direct assay
18276838 GOA
involved in doxorubicin metabolic process IDA
IDA: Inferred from direct assay
18276838 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1A1 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (17 - 293)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

  • HEL-S-165mP

AKR1A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKR1A1 P14550 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
AKR1A1 P14550 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
AKR1A1 P14550 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
AKR1A1 P14550 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
AKR1A1 P14550 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
AKR1A1 P14550 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
AKR1A1 P14550 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKR1A1 Proteins

Cat. No. Product Name Accession Purity
HY-P76137 AKR1A1 Protein, Human (His) P14550 (M1-Y325) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Fetal Alcohol Syndrome

  • Fetal Alcohol Spectrum Disorders

  • Arbd

  • Arnd

  • Alcohol-Related Birth Defects

  • Alcohol-Related Neurodevelopmental Disorder

  • Fas

  • Fasd

  • Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk

  • Alcohol Related Birth Defect

  • Alcohol Related Neurodevelopmental Disorder

  • Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk

  • Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk

  • Dysmorphism Due To Alcohol

  • Fetal Etoh Syndrome
Alcoholic Liver Cirrhosis

  • Alcoholic Cirrhosis

  • Portal Cirrhosis

  • Alcoholic Cirrhosis Of Liver

  • Liver Cirrhosis, Alcoholic

  • Laennec'S Cirrhosis

  • Laennec'S Cirrhosis, Alcoholic

  • Alcohol Cirrhosis

  • Alcoholic Laennec Cirrhosis

  • Alcoholic Cirrhosis Nos

  • Etoh Cirrhosis

  • Alcohol Hepatic Cirrhosis

  • Alcohol Liver Cirrhosis

  • Laennec Cirrhosis
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Liver Cirrhosis

  • Cirrhosis

  • Cirrhosis Of Liver

  • CIRRH

  • Cryptogenic Cirrhosis

  • Cirrhosis, Cryptogenic

  • Cirrhosis Nos
Metabolic Acidosis
Hypoascorbemia

  • Scurvy

  • Ascorbic Acid Deficiency

  • Vitamin C Deficiency

  • Vitamin C, Inability To Synthesize

  • Deficiency Of Vitamin C

  • Scorbutus

  • Vitamin C
Alcohol Use Disorder

  • Alcohol Abuse

  • Alcoholism

  • Ethanol Abuse

  • Alcohol Addiction

  • Alcohol Dependence

  • Alcoholic Intoxication, Chronic

  • Alcohol-Related Disorders
Cataract

  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
HY-156701 BAY-1128688 / Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 98.35% Unkown
HY-133708 β-Glucogallin 99.82% Unkown
HY-113114 Tetrahydrocortisone Substrate 99.97% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.87% Unkown
HY-D1341 Coumberone 99.73% Unkown
HY-N0310 Soyasaponin Bb 99.88% Unkown
HY-N8549A 5-Dihydrocortisone 99.83% Unkown
HY-N0412 Sesamoside Inhibitor 99.77% Unkown
HY-N2282 Zingiberen newsaponin 99.68% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177415 JSD26 Inhibitor / Unkown
HY-131586 3,7-Dihydroxyflavone 98.04% Unkown
HY-W069545 (S)-1-Tetralol 99.75% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-175331 ALR2-IN-7 Inhibitor 99.94% Unkown
HY-175639 ALR2-IN-8 Inhibitor / Unkown
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / Unkown
HY-181542 SG-55 / Unkown
HY-184928 S34-1040 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124432 CRT0093964 Inhibitor / Unkown
HY-RS17921 Akr1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24390 Akr1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKR1A1 RGD RGD:68346
Bos taurus AKR1A1 VGNC VGNC:25795
Felis catus AKR1A1 VGNC VGNC:59723
Mus musculus AKR1A1 MGD MGI:1929955
Macaca mulatta AKR1A1 VGNC VGNC:106319
Canis familiaris AKR1A1 VGNC VGNC:37768
Others AKR1A1 NCBI