Akr1a1 - aldo-keto reductase family 1 member A1 Gene

Also Known as Akr1a4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 78959

Summary

Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and cellular detoxification of aldehyde. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Akr1a1 Products (1)

mRNA Protein Name
NM_031000.3 NP_112262.1 aldo-keto reductase family 1 member A1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables L-glucuronate reductase activity IDA
IDA: Inferred from direct assay
22820017 RGD
enables glucuronolactone reductase activity IDA
IDA: Inferred from direct assay
22820017 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in D-glucuronate catabolic process IMP
IMP: Inferred from mutant phenotype
22820017 RGD
involved in L-ascorbic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
22820017 RGD
involved in cellular detoxification of aldehyde IDA
IDA: Inferred from direct assay
25152401 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
9538214 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member A1

  • 3-DG-reducing enzyme

  • alcohol dehydrogenase

  • aldehyde reductase

  • glucuronate reductase

  • glucuronolactone reductase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3
HY-156701 BAY-1128688 / Phase 2

Pre-clinical Phase

Bioactive Molecules (37)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 98.35% Unkown
HY-133708 β-Glucogallin 99.82% Unkown
HY-113114 Tetrahydrocortisone Substrate 99.97% Unkown
HY-114009 AKR1C1-IN-1 Inhibitor 99.87% Unkown
HY-D1341 Coumberone 99.73% Unkown
HY-N0310 Soyasaponin Bb 99.88% Unkown
HY-N8549A 5-Dihydrocortisone 99.83% Unkown
HY-N0412 Sesamoside Inhibitor 99.77% Unkown
HY-N2282 Zingiberen newsaponin 99.68% Unkown
HY-118819 5-Bromo-3-phenyl salicylic acid Inhibitor 98.00% Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177415 JSD26 Inhibitor 98.32% Unkown
HY-131586 3,7-Dihydroxyflavone 98.04% Unkown
HY-W069545 (S)-1-Tetralol 99.75% Unkown
HY-113850 CPSA Inhibitor / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-175331 ALR2-IN-7 Inhibitor 99.94% Unkown
HY-175639 ALR2-IN-8 Inhibitor / Unkown
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / Unkown
HY-181542 SG-55 / Unkown
HY-184928 S34-1040 Inhibitor / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00531 AKR1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00534 AKR1C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00538 AKR1D1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-124432 CRT0093964 Inhibitor / Unkown
HY-RS17921 Akr1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18415 Akr1d1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23471 Akr1c1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24390 Akr1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24896 Akr1d1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1a1 NCBI NCBI:10327