Nfkb1 - nuclear factor kappa B subunit 1 Gene

Also Known as EBP-1; NF-kB

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81736

About Nfkb1

Primary_assembly 2: 224,016,214-224,110,404 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 44 phenotypes. Biased expression in Spleen (RPKM 254.), Lung (RPKM 29.4) and 9 other tissues.

Summary

Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb1 Products (1)

mRNA Protein Name
NM_001276711.1 NP_001263640.1 nuclear factor NF-kappa-B p105 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
19414010 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
9718198 RGD
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
16135962 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10854252 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11313306 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
10854252 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16135962 RGD
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
9585425 RGD
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
14576180 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IDA
IDA: Inferred from direct assay
11520908 RGD
involved in cellular response to carbohydrate stimulus IDA
IDA: Inferred from direct assay
11146106 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cellular response to diterpene IDA
IDA: Inferred from direct assay
19765580 RGD
involved in cellular response to glucoside IDA
IDA: Inferred from direct assay
16842873 RGD
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
17726227 RGD
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
16842873 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
involved in cellular response to peptide IDA
IDA: Inferred from direct assay
19765580 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
18625500 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
9718198 RGD
involved in leukocyte migration involved in inflammatory response IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16354757 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
12742080 RGD
involved in response to bacterium IEP
IEP: Inferred from expression pattern
15777838 RGD
involved in response to copper ion IEP
IEP: Inferred from expression pattern
17418555 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
20211236 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
27939985 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
12193536 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
29091898 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
9343439 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nfkb1 Protein Structure

RHD-n_NFkB1

RHD-n_NFkB1: cd07935 (40 - 241)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (248 - 349)

ANK

ANK: sd00045 (502 - 537)

Ank_2

Ank_2: pfam12796 (535 - 609)

ANK

ANK: sd00045 (539 - 576)

ANK

ANK: sd00045 (580 - 609)

Ank_2

Ank_2: pfam12796 (583 - 677)

ANK

ANK: sd00045 (611 - 645)

ANK

ANK: sd00045 (647 - 677)

Ank_2

Ank_2: pfam12796 (652 - 728)

ANK

ANK: sd00045 (681 - 713)

Death_NFkB1_p105

Death_NFkB1_p105: cd08797 (813 - 887)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 973 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p105 subunit

  • DNA-binding factor KBF1

  • nuclear factor of kappa light chain gene enhancer in B-cells 1, p105

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19696B Tauroursodeoxycholate dihydrate 99.96% Yes
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9928 Alirocumab Inhibitor 97.00% Unkown

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0535 (+)-Magnoflorine chloride 99.29% Unkown
HY-N7922 Urolithin M5 Inhibitor 97.31% Unkown
HY-133987 AP-1/NF-κB activation inhibitor 1 Inhibitor 98.08% Unkown
HY-152177 JS6 Inhibitor 99.49% Unkown
HY-N0334A (+)-Magnoflorine iodide 99.74% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-49444 EN450 Degrader 98.59% Unkown
HY-N7627 Regaloside C 99.62% Unkown
HY-174138 NF-κB degrader 1 Degrader 99.92% Unkown
HY-N0772 Isomangiferin 99.60% Unkown
HY-RS09254 NFKB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3532 Cannabisin F Modulator 96.0% Unkown
HY-N0334 (+)-Magnoflorine / Unkown
HY-180580 SMU-C409 / Unkown
HY-184654 MR-39 / Unkown
HY-P5762A Phoenixin-14 TFA / Unkown
HY-RS09255 Nfkb1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09256 Nfkb1 Rat Pre-designed siRNA Set A / Unkown
HY-W995241 BPD Inhibitor / Unkown
HY-174569 Human NFKB1 mRNA / Unkown
HY-N15315 Triptriolide / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9928A Alirocumab (anti-PCSK9) Inhibitor 98.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb1 NCBI NCBI:4790