2. Gene
  3. Nfkb1 - nuclear factor kappa B subunit 1 Gene

Nfkb1 - nuclear factor kappa B subunit 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as EBP-1; NF-kB

Gene ID: 81736 | Gene type: protein coding

About Nfkb1

Primary_assembly 2: 224,016,214-224,110,404 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 44 phenotypes. Biased expression in Spleen (RPKM 254.), Lung (RPKM 29.4) and 9 other tissues.

Summary

Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfkb1 Products(1)

mRNA Protein Name
NM_001276711.1 NP_001263640.1 nuclear factor NF-kappa-B p105 subunit

Nfkb1 Protein Structure

RHD-n_NFkB1

RHD-n_NFkB1: cd07935 (40 - 241)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (248 - 349)

ANK

ANK: sd00045 (502 - 537)

Ank_2

Ank_2: pfam12796 (535 - 609)

ANK

ANK: sd00045 (539 - 576)

ANK

ANK: sd00045 (580 - 609)

Ank_2

Ank_2: pfam12796 (583 - 677)

ANK

ANK: sd00045 (611 - 645)

ANK

ANK: sd00045 (647 - 677)

Ank_2

Ank_2: pfam12796 (652 - 728)

ANK

ANK: sd00045 (681 - 713)

Death_NFkB1_p105

Death_NFkB1_p105: cd08797 (813 - 887)

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  • 973 a.a.
Protein Preferred Names Protein Names

nuclear factor NF-kappa-B p105 subunit

DNA-binding factor KBF1

nuclear factor of kappa light chain gene enhancer in B-cells 1, p105

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133987 AP-1/NF-κB activation inhibitor 1 Inhibitor 99.03% Unkown
HY-49444 EN450 Degrader 99.28% Unkown
HY-N0001S (±)-Epicatechin-13C3 / Unkown
HY-RS09254 NFKB1 Human Pre-designed siRNA Set A / Unkown
HY-RS09255 Nfkb1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09256 Nfkb1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkb1 NCBI NCBI:4790