GSK-2256098 hydrochloride
Based on 13 publication(s) in Google Scholar
GSK-2256098 hydrochloride is a focal adhesion kinase (FAK) inhibitor that exhibits potential antiangiogenic and antineoplastic activities. GSK-2256098 hydrochloride targets FAK to inhibit tumor cell growth by regulating cell adhesion, migration, proliferation, and survival.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 1416771-10-2
- Formula: C20H24Cl2N6O2
- Molecular Weight:451.35
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GSK-2256098 hydrochloride
More- Nat Mater. 2025 Sep 5. [Abstract]
- Autophagy. 2026 May 29:1-15. [Abstract]
- Sci Adv. 2026 Jan 30;12(5):eady8382. [Abstract]
- Cell Death Dis. 2025 Mar 27;16(1):210. [Abstract]
- Oncogene. 2025 Sep 30. [Abstract]
- JCI Insight. 2020 Feb 13;5(3):e133232. [Abstract]
- Biochem Pharmacol. 2026 Jun 25;251(Pt 2):118189. [Abstract]
- Cell Biol Toxicol. 2024 Jul 12;40(1):54. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Aug 18;1871(8):168023. [Abstract]
- J Cell Physiol. 2024 Nov;239(11):e31359. [Abstract]
- Cell Immunol. 2026 Apr 6:425:105103. [Abstract]
- bioRxiv. 2024 Jun 28:2024.06.28.601153. [Abstract]
- Research Square Preprint. 2024 Jan 31.
Biological Activity
Chemical Information
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CAS No. 1416771-10-2
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Appearance Solid
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Molecular Weight 451.35
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Formula C20H24Cl2N6O2
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Color White to off-white
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SMILES
O=C(NOC)C1=CC=CC=C1NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Nat Mater
Local photocrosslinking of native tissue matrix regulates lung epithelial cell mechanosensing and function. [Abstract]2025 Sep 5. PMID: 40913159 -
Autophagy
PTK2/FAK inhibition triggers TMED9-mediated protective autophagy in pancreatic cancer cell via enhancing ERGIC-ERES contact. [Abstract]2026 May 29:1-15. PMID: 42144738 -
Sci Adv
Inhibition of focal adhesion kinase impairs tumor formation and preserves hearing in a murine model of NF2-related schwannomatosis. [Abstract]2026 Jan 30;12(5):eady8382. PMID: 41616055 -
Cell Death Dis
Role of the PI3K/AKT signaling pathway in the cellular response to Tumor Treating Fields (TTFields). [Abstract]2025 Mar 27;16(1):210. PMID: 40148314 -
Oncogene
C1QBP forms a positive feedback loop with the PAICS/FAK/C-MYC axis to promote cancer cell proliferation. [Abstract]2025 Sep 30. PMID: 41028903 -
JCI Insight
2020 Feb 13;5(3):e133232. PMID: 32051338 -
Biochem Pharmacol
2026 Jun 25;251(Pt 2):118189. PMID: 42349620 -
Cell Biol Toxicol
TRAF6 promotes spinal microglial M1 polarization to aggravate neuropathic pain by activating the c-JUN/NF-kB signaling pathway. [Abstract]2024 Jul 12;40(1):54. PMID: 38995476 -
Biochim Biophys Acta Mol Basis Dis
Inhibition of ELOVL6 activity impairs mitochondrial respiratory function and inhibits tumor progression in FGFR3-mutated bladder cancer cells. [Abstract]2025 Aug 18;1871(8):168023. PMID: 40835210 -
J Cell Physiol
Ankrd1 inhibits the FAK/Rho-GTPase/F-actin pathway by downregulating ITGA6 transcriptional to regulate myoblast functions. [Abstract]2024 Nov;239(11):e31359. PMID: 38988048 -
Cell Immunol
WISP-3 enhances proinflammatory cytokine IL-1β production in rheumatoid arthritis through the FAK, JNK and AP-1 pathways. [Abstract]2026 Apr 6:425:105103. PMID: 41955703 -
bioRxiv
Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A. [Abstract]2024 Jun 28:2024.06.28.601153. PMID: 38979143 -
Solvent & Solubility
DMSO : 100 mg/mL (221.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2156 mL | 11.0779 mL | 22.1558 mL | 55.3894 mL |
| 5 mM | 0.4431 mL | 2.2156 mL | 4.4312 mL | 11.0779 mL | |
| 10 mM | 0.2216 mL | 1.1078 mL | 2.2156 mL | 5.5389 mL | |
| 15 mM | 0.1477 mL | 0.7385 mL | 1.4771 mL | 3.6926 mL | |
| 20 mM | 0.1108 mL | 0.5539 mL | 1.1078 mL | 2.7695 mL | |
| 25 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2156 mL | |
| 30 mM | 0.0739 mL | 0.3693 mL | 0.7385 mL | 1.8463 mL | |
| 40 mM | 0.0554 mL | 0.2769 mL | 0.5539 mL | 1.3847 mL | |
| 50 mM | 0.0443 mL | 0.2216 mL | 0.4431 mL | 1.1078 mL | |
| 60 mM | 0.0369 mL | 0.1846 mL | 0.3693 mL | 0.9232 mL | |
| 80 mM | 0.0277 mL | 0.1385 mL | 0.2769 mL | 0.6924 mL | |
| 100 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5539 mL |
GSK-2256098 hydrochloride Related Classifications
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