1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC6-IN-11

HDAC6-IN-11 

Cat. No.: HY-150694
Handling Instructions

HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells.

For research use only. We do not sell to patients.

HDAC6-IN-11 Chemical Structure

HDAC6-IN-11 Chemical Structure

CAS No. : 2409072-27-9

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Description

HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].

IC50 & Target

HDAC6

20.7 nM (IC50)

HDAC8

7750 nM (IC50)

In Vitro

HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1].
HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: A549 and HCT116 cells
Concentration: 0.44-6.68 μM
Incubation Time: 48 hours
Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively).

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM
Incubation Time: 48 hours
Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
Molecular Weight

336.34

Formula

C19H16N2O4

CAS No.
SMILES

O=C(NO)/C=C/C1=NC2=CC=C(OC3=CC=C(OC)C=C3)C=C2C=C1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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HDAC6-IN-11
Cat. No.:
HY-150694
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