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Cat. No.: HY-187393

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hIgG-hFc receptor-IN-2

hIgG-hFc receptor-IN-2 is a hFcRn inhibitor with an IC₅₀ of 6 μM for human hFcRn. hIgG-hFc receptor-IN-2 blocks the protein-protein interaction between human IgG and the soluble extracellular domain of hFcRn. hIgG-hFc receptor-IN-2 serves as a tool for studying FcRn biology and a starting point for developing orally available small molecule hFcRn inhibitors. hIgG-hFc receptor-IN-2 can be used for the research of autoimmune disease.

For research use only. We do not sell to patients.

CAS No.: 1425051-06-4
Formula: C₂₆H₂₉N₅O₂
Molecular Weight:443.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

hIgG-hFc receptor-IN-2 Chemical Structure

CAS No.: 1425051-06-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

hIgG-hFc receptor-IN-2 (Compound 50) inhibits the interaction between human IgG and soluble extracellular domain of human FcRn in an ELISA-based competition assay with an IC₅₀ of 6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1425051-06-4
Molecular Weight 443.54
Formula C₂₆H₂₉N₅O₂
SMILES

N#CC(C1=NC2=C(N=C1N3CCCCCCC3)C=CC=C2)C(NCC4=CC(OC)=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang Z, et al. Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction. Bioorganic & medicinal chemistry letters. 2013 Mar 01;23(5):1253-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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