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Cat. No.: HY-130760

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HIV-1 integrase inhibitor 7

HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC₅₀ of 33.3 nM.

For research use only. We do not sell to patients.

CAS No.: 204268-03-1
Formula: C₃₀H₂₆O₁₆
Molecular Weight:642.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HIV-1 integrase inhibitor 7 Chemical Structure

CAS No.: 204268-03-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC₅₀ of 33.3 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	16 μM Compound: 6	Compound was evaluated for the cytoprotection by XTT cytoprotection assay through the NCI AIDS Screen Compound was evaluated for the cytoprotection by XTT cytoprotection assay through the NCI AIDS Screen	[PMID: 10212126]
CEM-SS	IC₅₀	50 μM Compound: 6	Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen	[PMID: 10212126]
MT4	EC₅₀	10.1 μM Compound: 6	Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-2 (ROD) Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-2 (ROD)	[PMID: 10212126]
MT4	EC₅₀	4.1 μM Compound: 6	Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa) Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa)	[PMID: 10212126]
MT4	IC₅₀	47.1 μM Compound: 6	Concentration of compound required to reduce MT-4 cell viability by 50% Concentration of compound required to reduce MT-4 cell viability by 50%	[PMID: 10212126]

Chemical Information

CAS No. 204268-03-1
Molecular Weight 642.52
Formula C₃₀H₂₆O₁₆
SMILES

O=C(O)[C@H](OC(/C=C/C1=CC=C(OC(C)=O)C(OC(C)=O)=C1)=O)[C@@H](OC(/C=C/C2=CC=C(OC(C)=O)C(OC(C)=O)=C2)=O)C(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Saíz-Urra L, et al. Quantitative structure-activity relationship studies of HIV-1 integrase inhibition. 1. GETAWAY descriptors. Eur J Med Chem. 2007 Jan;42(1):64-70. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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