HIV-1 integrase inhibitor 7

製品番号: HY-130760: Data Sheet 取扱説明書
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HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC₅₀ of 33.3 nM.

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HIV-1 integrase inhibitor 7 構造式

CAS 番号 : 204268-03-1

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MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

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製品説明

HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor, with an IC₅₀ of 33.3 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	16 μM Compound: 6	Compound was evaluated for the cytoprotection by XTT cytoprotection assay through the NCI AIDS Screen Compound was evaluated for the cytoprotection by XTT cytoprotection assay through the NCI AIDS Screen	[PMID: 10212126]
CEM-SS	IC₅₀	50 μM Compound: 6	Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen	[PMID: 10212126]
MT4	EC₅₀	10.1 μM Compound: 6	Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-2 (ROD) Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-2 (ROD)	[PMID: 10212126]
MT4	EC₅₀	4.1 μM Compound: 6	Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa) Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa)	[PMID: 10212126]
MT4	IC₅₀	47.1 μM Compound: 6	Concentration of compound required to reduce MT-4 cell viability by 50% Concentration of compound required to reduce MT-4 cell viability by 50%	[PMID: 10212126]

分子量

642.52

分子式

C₃₀H₂₆O₁₆

CAS 番号

204268-03-1

SMILES

O=C(O)[C@H](OC(/C=C/C1=CC=C(OC(C)=O)C(OC(C)=O)=C1)=O)[C@@H](OC(/C=C/C2=CC=C(OC(C)=O)C(OC(C)=O)=C2)=O)C(O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Saíz-Urra L, et al. Quantitative structure-activity relationship studies of HIV-1 integrase inhibition. 1. GETAWAY descriptors. Eur J Med Chem. 2007 Jan;42(1):64-70. [Content Brief]