BRL-15572
Based on 1 Customer Validation
BRL-15572 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
For research use only. We do not sell to patients.
- Purity: 98.31%
- CAS No.: 734517-40-9
- Formula: C25H27ClN2O
- Molecular Weight:406.95
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1D Receptor |
Chemical Information
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CAS No. 734517-40-9
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Appearance Solid
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Molecular Weight 406.95
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Formula C25H27ClN2O
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SMILES
OC(C(C1=CC=CC=C1)C2=CC=CC=C2)CN3CCN(C4=CC=CC(Cl)=C4)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 41.67 mg/mL (102.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Price GW, et, al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep; 356(3): 312-20. [Content Brief]
[2]. Geovanna NQ, et, al. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr; 29(2 and 3-Spec Issue): 270-279. [Content Brief]
[3]. Hagan JJ, et, al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23; 331(2-3): 169-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4573 mL | 12.2865 mL | 24.5730 mL | 61.4326 mL |
| 5 mM | 0.4915 mL | 2.4573 mL | 4.9146 mL | 12.2865 mL | |
| 10 mM | 0.2457 mL | 1.2287 mL | 2.4573 mL | 6.1433 mL | |
| 15 mM | 0.1638 mL | 0.8191 mL | 1.6382 mL | 4.0955 mL | |
| 20 mM | 0.1229 mL | 0.6143 mL | 1.2287 mL | 3.0716 mL | |
| 25 mM | 0.0983 mL | 0.4915 mL | 0.9829 mL | 2.4573 mL | |
| 30 mM | 0.0819 mL | 0.4096 mL | 0.8191 mL | 2.0478 mL | |
| 40 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5358 mL | |
| 50 mM | 0.0491 mL | 0.2457 mL | 0.4915 mL | 1.2287 mL | |
| 60 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0239 mL | |
| 80 mM | 0.0307 mL | 0.1536 mL | 0.3072 mL | 0.7679 mL | |
| 100 mM | 0.0246 mL | 0.1229 mL | 0.2457 mL | 0.6143 mL |
BRL-15572 Related Classifications
HY-13200B Related Classifications
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