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Cat. No.: HY-N20642

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Humilinolide A

Humilinolide A is a limonoid compound. Humilinolide A can be isolated from Swietenia humilis. Humilinolide A binds to estrogen-dependent receptors on the plasma membrane of the myometrium, thereby triggering uterine contraction responses. Humilinolide A induces irreversible, concentration-dependent increases in the tension, amplitude and frequency of smooth muscle contraction. Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with a IC₅₀ of 99.0 µg/mL. Humilinolide A exhibits antifeedant activity. Humilinolide A can be used in studies related to gastrointestinal motility regulation and reproductive smooth muscle function.

For research use only. We do not sell to patients.

CAS No.: 152110-04-8
Formula: C₃₁H₄₀O₁₁
Molecular Weight:588.64

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Please store the product under the recommended conditions in the Certificate of Analysis.

Humilinolide A Chemical Structure

CAS No.: 152110-04-8

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Biological Activity

Description

All Estrogen Receptor/ERR Isoforms :

In Vitro

Humilinolide A (3.1-200 μM) induces irreversible, concentration-dependent spasmogenic effects on isolated ileal smooth muscles of male Hartley guinea pigs, with an EC₅₀ of 120 μM and a maximum excitability of 59.71%^[1].
Humilinolide A (3.1-200 μM) exerts irreversible, concentration-dependent uterine contractile effects on isolated uterine smooth muscles of Wistar rats. It shows the highest potency in estrous rats (EC₅₀ 25 μM) and estrogen-pretreated rats (EC₅₀ 31.5 μM), has negligible effects in diestrous rats, and exhibits weak activity in ovariectomized rats^[1].
Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with an IC₅₀ value of 99.0 µg/mL^[2].
Humilinolide A (50-200 μg/mL; 24 h for Amaranthus hypochondriacus, 48 h for Echinocloa crus-galli) inhibits radicle growth of Echinocloa crus-galli with an IC₅₀ value of 99.06 μg/mL, and also inhibits radicle growth of Amaranthus hypochondriacus with an IC₅₀ value of 199.0 μg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 152110-04-8
Molecular Weight 588.64
Formula C₃₁H₄₀O₁₁
SMILES

O[C@@]12[C@]3([H])[C@@]4(O3)[C@@](CC[C@@]5([C@@]4([H])CC(O[C@H]5C6=COC=C6)=O)C)([H])[C@@](C1=O)([C@@](C(C)([C@@H]2OC(C(C)C)=O)C)([H])[C@@H](O)C(OC)=O)C
Structure Classification
- Terpenoids
- Tetracyclic Triterpenoids
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Perusquía M, et al. Contractile response induced by a limonoid (humilinolide A) on spontaneous activity of isolated smooth muscle[J]. Phytotherapy Research: An International Journal Devoted to Medical and Scientific Research on Plants and Plant Products, 1997, 11(5): 354-357.

[2]. Narender T, et al. Occurrence, biosynthesis, biological activity and NMR spectroscopy of D and B, D ring seco-limonoids of Meliaceae family[J]. Natural Product Communications, 2007, 2(2): 1934578X0700200219.

[3]. Segura-Correa R, et al. New tetranortriterpenoids from Swietenia humilis[J]. Journal of Natural Products, 1993, 56(9): 1567-1574.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Humilinolide A

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Humilinolide A Related Classifications

HY-N20642 Related Classifications