Humilinolide A 

Humilinolide A is a limonoid compound. Humilinolide A can be isolated from Swietenia humilis. Humilinolide A binds to estrogen-dependent receptors on the plasma membrane of the myometrium, thereby triggering uterine contraction responses. Humilinolide A induces irreversible, concentration-dependent increases in the tension, amplitude and frequency of smooth muscle contraction. Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with a IC₅₀ of 99.0 µg/mL. Humilinolide A exhibits antifeedant activity. Humilinolide A can be used in studies related to gastrointestinal motility regulation and reproductive smooth muscle function^[1][2][3].

Humilinolide A (3.1-200 μM) induces irreversible, concentration-dependent spasmogenic effects on isolated ileal smooth muscles of male Hartley guinea pigs, with an EC₅₀ of 120 μM and a maximum excitability of 59.71%^[1].
Humilinolide A (3.1-200 μM) exerts irreversible, concentration-dependent uterine contractile effects on isolated uterine smooth muscles of Wistar rats. It shows the highest potency in estrous rats (EC₅₀ 25 μM) and estrogen-pretreated rats (EC₅₀ 31.5 μM), has negligible effects in diestrous rats, and exhibits weak activity in ovariectomized rats^[1].
Humilinolide A inhibits radicle growth of barnyard grass (Echinochloa crus-galli) with an IC₅₀ value of 99.0 µg/mL^[2].
Humilinolide A (50-200 μg/mL; 24 h for Amaranthus hypochondriacus, 48 h for Echinocloa crus-galli) inhibits radicle growth of Echinocloa crus-galli with an IC₅₀ value of 99.06 μg/mL, and also inhibits radicle growth of Amaranthus hypochondriacus with an IC₅₀ value of 199.0 μg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

588.64

C₃₁H₄₀O₁₁

152110-04-8

O[C@@]12[C@]3([H])[C@@]4(O3)[C@@](CC[C@@]5([C@@]4([H])CC(O[C@H]5C6=COC=C6)=O)C)([H])[C@@](C1=O)([C@@](C(C)([C@@H]2OC(C(C)C)=O)C)([H])[C@@H](O)C(OC)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Perusquía M, et al. Contractile response induced by a limonoid (humilinolide A) on spontaneous activity of isolated smooth muscle[J]. Phytotherapy Research: An International Journal Devoted to Medical and Scientific Research on Plants and Plant Products, 1997, 11(5): 354-357.

  [2]. Narender T, et al. Occurrence, biosynthesis, biological activity and NMR spectroscopy of D and B, D ring seco-limonoids of Meliaceae family[J]. Natural Product Communications, 2007, 2(2): 1934578X0700200219.

  [3]. Segura-Correa R, et al. New tetranortriterpenoids from Swietenia humilis[J]. Journal of Natural Products, 1993, 56(9): 1567-1574.