ANXA5 - annexin A5 Gene
Also Known as PP4; ANX5; ENX2; CPB-I; RPRGL3; HEL-S-7; VAC-alph
Species: Homo sapiens
About ANXA5
This gene has 11 transcripts (splice variants), 288 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 198.4), placenta (RPKM 170.8) and 25 other tissues.
Summary
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a Phospholipase A2 and protein kinase C inhibitory protein with Calcium Channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]
ANXA5 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001154.4 | NP_001145.1 | annexin A5 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables calcium-dependent phospholipid binding |
IDA
IDA: Inferred from direct assay
|
2138016 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
21044950 | GOA |
ANXA5 Protein Structure
Annexin: Annexin (20 - 84)
Annexin: Annexin (91 - 156)
Annexin: Annexin (174 - 239)
Annexin: Annexin (251 - 315)
- 0
- 100
- 200
- 300
- 320 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
annexin A5 |
|
ANXA5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
ANXA5 | P08758 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
ANXA5 | P08758 | GSC2 | Homo sapiens | O15499 | 32296183 | |
|
Intra
|
ANXA5 | P08758 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | TINF2 | Homo sapiens | Q9BSI4 | 21044950 | |
|
Intra
|
ANXA5 | P08758 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | OPTN | Homo sapiens | Q96CV9 | 32814053 | |
|
Intra
|
ANXA5 | P08758 | OPTN | Homo sapiens | Q96CV9 | 32814053 |
Recombinant ANXA5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7517 | Annexin A5/ANXA5 Protein, Human (solution) | P08758 (A2-D320) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700015AF | Animal-Free Annexin A5/ANXA5 Protein, Human (His) | P08758 (M1-D320) | ≥ 95%, as determined by reducing SDS-PAGE. |
ANXA5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82084 | Annexin V Antibody (YA1829) | WB, ICC/IF | Human, Mouse, Rat |
| HY-P82084A | Annexin V Antibody (YA1829)(PBS only) | WB, ICC/IF | Human, Mouse, Rat |
| HY-P84022 | Annexin V Antibody (YA3719) | WB, ICC/IF, FC, ELISA | Human, Mouse |
| HY-P84022A | Annexin V Antibody (YA3719)(PBS only) | WB, ICC/IF, FC, ELISA | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pregnancy Loss, Recurrent 3 |
|
|
| Antiphospholipid Syndrome |
|
|
| Childhood T-Cell Acute Lymphoblastic Leukemia |
|
|
| Overhydrated Hereditary Stomatocytosis |
|
|
| Thrombophilia |
|
|
| Colon Adenocarcinoma |
|
|
| Barth Syndrome |
|
|
| Thrombosis |
|
|
| Ovarian Cancer |
|
|
| Colorectal Cancer |
|
|
| Beta-Thalassemia |
|
|
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
| Amelanotic Melanoma |
|
|
| Glioblastoma |
|
|
| Arthritis |
|
|
| Pancreatic Cancer |
|
|
| Placenta Disease |
|
|
| Pre-Eclampsia |
|
|
| Osteonecrosis |
|
|
| Toxoplasmosis |
|
|
| Lung Cancer |
|
|
| Systemic Lupus Erythematosus |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Arteriosclerosis |
|
|
| Bladder Cancer |
|
|
| Myelodysplastic Syndrome |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Thrombocytopenia |
|
|
| Endometrial Cancer |
|
|
| Bone Cancer |
|
|
| Tongue Carcinoma |
|
|
| Myocardial Infarction |
|
|
| Prostate Cancer |
|
|
| Rheumatoid Arthritis |
|
|
| Malaria |
|
|
| Disease By Infectious Agent |
|
|
| Myeloma, Multiple |
|
|
| Glycogen Storage Disease |
|
|
| Melanoma |
|
|
| Cerebral Palsy |
|
|
| Gastric Cancer |
|
|
| Breast Adenocarcinoma |
|
|
| Cystic Fibrosis |
|
|
| Osteogenic Sarcoma |
|
|
| Gallbladder Cancer |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Neuroblastoma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Leukemia, Acute Monocytic |
|
|
| Esophageal Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Melanoma, Uveal |
|
|
| Medulloblastoma |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Stroke, Ischemic |
|
|
| Phenylketonuria |
|
|
| Cervix Carcinoma |
|
|
| Mantle Cell Lymphoma |
|
|
| Diabetes Mellitus |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Breast Cancer |
|
|
| Leukemia, Acute Myeloid |
|
|
| Peripheral Nervous System Disease |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Connective Tissue Disease |
|
|
| Nervous System Disease |
|
|
| Eye Disease |
|
|
| Skin Disease |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | ANXA5 | VGNC | VGNC:25967 |
| Felis catus | ANXA5 | VGNC | VGNC:67700 |
| Rattus norvegicus | ANXA5 | RGD | RGD:2120 |
| Macaca mulatta | ANXA5 | VGNC | VGNC:69950 |
| Canis familiaris | ANXA5 | VGNC | VGNC:37942 |
| Mus musculus | ANXA5 | MGD | MGI:106008 |
| Others | ANXA5 | NCBI |