Iodoacetamide-PEG5-azide

Name: Iodoacetamide-PEG5-azide
Brand: MedChemExpress
SKU: HY-134687
Rating: 4.5 (0 reviews)

製品番号: HY-134687 純度: 97.64%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Iodoacetamide-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodoacetamide-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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Iodoacetamide-PEG5-azide 構造式

容量	価格（税別）	在庫状況	数量
5 mg	$109	在庫あり	Estimated Time of Arrival: December 31
10 mg	$170	在庫あり	Estimated Time of Arrival: December 31
25 mg	$340	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Iodoacetamide-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Iodoacetamide-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

PEGs

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

474.29

分子式

C₁₄H₂₇IN₄O₆

Appearance

Liquid

Color

Light yellow to yellow

SMILES

O=C(NCCOCCOCCOCCOCCOCCN=[N+]=[N-])CI

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

純度: 98.58%

Select Batch:

データシート (262 KB) SDS (251 KB)

COA (239 KB) HNMR (256 KB) LCMS (93 KB)

取扱説明書 (2659 KB)

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]