Iodoacetamide-PEG5-NH2

Cat. No.: HY-134688: Data Sheet Handling Instructions
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Iodoacetamide-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

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Iodoacetamide-PEG5-NH2 화학구조

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Iodoacetamide-PEG5-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

448.29

화학식

C₁₄H₂₉IN₂O₆

SMILES

O=C(NCCOCCOCCOCCOCCOCCN)CI

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

용액&용해도

In Vitro:

DMSO : 5 mg/mL (11.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2307 mL	11.1535 mL	22.3070 mL
5 mM	0.4461 mL	2.2307 mL	4.4614 mL
10 mM	0.2231 mL	1.1153 mL	2.2307 mL

View the Complete Stock Solution Preparation Table

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2307 mL	11.1535 mL	22.3070 mL	55.7675 mL
	5 mM	0.4461 mL	2.2307 mL	4.4614 mL	11.1535 mL
	10 mM	0.2231 mL	1.1153 mL	2.2307 mL	5.5767 mL