BpV(phen) trihydrate
Based on 3 publication(s) in Google Scholar
BpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity.
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- 純度: 98.0%
- CAS 番号: 171202-16-7
- 分子式: C12H14KN2O8V
- 分子量:404.29
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 BpV(phen) trihydrate
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生物活性
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Leishmania |
BpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells[1].
BpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment increases the apoptosis of H/R-injured H9c2 cells[1].
BpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells[1].
After stimulation of BpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited[1].
BpV(phen) is an insulin-mimetic agent following insulin-receptor tyrosine kinase hyperphosphorylation and activation[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:5 μM
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Incubation Time:24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:Caused a further decrease of cell viability.
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Cell Line:Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:5 μM
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Incubation Time:24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:Increased the apoptosis of H/R-injured H9c2 cells.
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Cell Line:Hypoxia/reoxygenation (H/R)-injured H9c2 cells
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Concentration:5 μM
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Incubation Time:24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes)
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Result:Showed an increased release of Cytochrome C.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells[2]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily; for 38 days
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Result:Caused a significant reduction in average tumor volume.
化学情報
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CAS 番号 171202-16-7
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性状 Solid
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分子量 404.29
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分子式 C12H14KN2O8V
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Color Yellow to orange
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SMILES
O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.O.O.O.[K+]
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別名
Bisperoxovanadium(phen) trihydrate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. [Abstract]2022 May 19;13(1):2762. PMID: 35589797 -
Biochem Bioph Res Co
2020 Sep 3;529(4):1045-1052. PMID: 32819563 -
Am J Mens Health
The Guangsi Yulin Decoction Inhibits Oxidative Stress and Inflammation-Induced Spermatogenesis Dysfunction via the PTEN/ PI3K/ AKT/ FoxO1 Pathway. [Abstract]2026 Mar-Apr;20(2):15579883261427164. PMID: 41807111
溶剤 & 溶解度
H2O : 100 mg/mL (247.35 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (61.84 mM); Clear solution; Need ultrasonic and warming
純度とドキュメンテーション
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データシート (298 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55(9):741-748. [Content Brief]
[2]. Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262(2):265-75. [Content Brief]
[3]. Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566(1-3):35-8. [Content Brief]
[4]. Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). Mol Endocrinol. 1997 Dec;11(13):1899-910. [Content Brief]
[5]. Chen Q, et al. Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290(43):26051-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4735 mL | 12.3674 mL | 24.7347 mL | 61.8368 mL |
| 5 mM | 0.4947 mL | 2.4735 mL | 4.9469 mL | 12.3674 mL | |
| 10 mM | 0.2473 mL | 1.2367 mL | 2.4735 mL | 6.1837 mL | |
| 15 mM | 0.1649 mL | 0.8245 mL | 1.6490 mL | 4.1225 mL | |
| 20 mM | 0.1237 mL | 0.6184 mL | 1.2367 mL | 3.0918 mL | |
| 25 mM | 0.0989 mL | 0.4947 mL | 0.9894 mL | 2.4735 mL | |
| 30 mM | 0.0824 mL | 0.4122 mL | 0.8245 mL | 2.0612 mL | |
| 40 mM | 0.0618 mL | 0.3092 mL | 0.6184 mL | 1.5459 mL | |
| 50 mM | 0.0495 mL | 0.2473 mL | 0.4947 mL | 1.2367 mL | |
| 60 mM | 0.0412 mL | 0.2061 mL | 0.4122 mL | 1.0306 mL | |
| 80 mM | 0.0309 mL | 0.1546 mL | 0.3092 mL | 0.7730 mL | |
| 100 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6184 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BpV(phen) trihydrate 関連分類
HY-122818 関連分類
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- BpV(phen)
- 171202-16-7
- Bisperoxovanadium(phen)
- PTEN
- Phosphatase
- Parasite
- Apoptosis
- PTP
- Cytochrome C
- mitochondria
- hypoxia
- reoxygenation
- PINK1
- Peroxovanadiums
- anti-tumor
- anti-proliferative Hypoxia/reoxygenation (H/R)-injured H9c2 cells[1] 5 μM 24.5 hours (hypoxia for 24 h
- reoxygenation for 30 minutes) Increased the apoptosis of H/R-injured H9c2 cells. Hypoxia/reoxygenation (H/R)-injured H9c2 cells[1] 5 μM 24.5 hours (hypoxia for 24 h
- reoxygenation for 30 minutes) Showed an increased release of Cytochrome C.
- Inhibitor
- inhibitor
- inhibit