country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-P11919

Copy Link Print Information

D-T7-cys

D-T7-cys is a D-T7 (HY-P11918) peptide with a C-terminal D-cysteine (HY-W018555). Nanoparticles modified with D-T7-cys serve as effective carriers for the delivery of compounds targeting the transferrin receptor (TfR). D-T7-cys reacts with DOX-SS-Pyr to form the DT7-SS-DOX conjugate. D-T7-cys is applicable to research related to glioma, autism spectrum disorder, glioblastoma, hepatocellular carcinoma, and lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2422045-23-4
分子式: C₄₄H₆₅N₁₅O₁₀S
分子量:996.15

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

D-T7-cys 構造式

CAS 番号: 2422045-23-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

D-T7-cys reacts with DOX-SS-Pyr via disulfide bond exchange to form the DT7-SS-DOX conjugate with high purity and confirmed structure^[3].
DT7-SS-DOX (constructed from D-T7-cys) exhibits significantly higher stability in mouse serum than LT7-SS-DOX, with a half-life of 8.58 h^[3].
DT7-SS-DOX (constructed from D-T7-cys) (48 h) exhibits dose-dependent antiproliferative activity against U87, HepG2 and A549 tumor cells with high transferrin receptor (TfR) expression (with IC₅₀ values ranging from 5.70 µM to 20.61 µM), while showing extremely low cytotoxicity toward LO2 normal cells with low TfR expression (IC₅₀ > 100 µM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

TfR-overexpressed U87, HepG2, A549 tumor cells; TfR-low-expressed LO2 normal liver cells
Concentration:

DT7-SS-DOX (serial equivalent DOX concentrations up to 40 µM)
Incubation Time:

48 h
Result:

Inhibited tumor cell proliferation in a dose-dependent manner, with IC₅₀ values of 5.70 µM (U87), 7.01 µM (HepG2), and 20.61 µM (A549).
Exhibited significantly reduced toxicity to LO2 normal cells, with an IC₅₀ value > 100 µM.

化学情報

CAS 番号 2422045-23-4
分子量 996.15
分子式 C₄₄H₆₅N₁₅O₁₀S
配列

d{His-Arg-Pro-Tyr-Ile-Ala-His-Cys}
シーケンスの短縮

d{HRPYIAHC}
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Yu M, et al. D-T7 Peptide-Modified PEGylated Bilirubin Nanoparticles Loaded with Cediranib and Paclitaxel for Antiangiogenesis and Chemotherapy of Glioma. ACS applied materials & interfaces. 2019 Jan 09;11(1):176-186.

[2]. He X, et al. Acid-Responsive Dual-Targeted Nanoparticles Encapsulated Aspirin Rescue the Immune Activation and Phenotype in Autism Spectrum Disorder. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 May;9(14):e2104286.

[3]. Yu J, et al. New Transferrin Receptor-Targeted Peptide-Doxorubicin Conjugates: Synthesis and In Vitro Antitumor Activity. Molecules (Basel, Switzerland). 2024 Apr 12;29(8):1758. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ