Danofloxacin
Based on 1 Customer Validation
Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.56%
- CAS 番号: 112398-08-0
- 分子式: C19H20FN3O3
- 分子量:357.38
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Quinolone |
Danofloxacin (20 h) exhibits significant in vitro inhibitory activity against Escherichia coli isolates from Gushi chickens, with an MIC50 of 0.5 μg/mL; the MIC50 against the quality control strain E. coli ATCC 25922 is 0.125 μg/mL[1].
Danofloxacin (0.008-128 μg/mL; 20 h) exhibits certain inhibitory activity against swine-derived Escherichia coli isolates, with an MIC50 of 4 μg/mL and an MIC90 of 128 μg/mL. The epidemiological cut-off value covering the wild-type population is 8 μg/mL[3].
Danofloxacin (1/4 MIC-32× MIC; 0-24 h) exhibits concentration-dependent bactericidal activity against the Escherichia coli strain JLP95, with significant efficacy observed at concentrations of 4× MIC and above[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 112398-08-0
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性状 Solid
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分子量 357.38
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分子式 C19H20FN3O3
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Color Off-white to light yellow
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SMILES
O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O
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別名
ダノフロキサシン
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
1 M NaOH : 100 mg/mL (279.81 mM; ultrasonic and warming and heat to 60°C)
H2O : 2 mg/mL (5.60 mM; ultrasonic and warming and adjust pH to 11 with 1 M NaOH and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Chen JC, et al. In vitro antibacterial activity of danofloxacin against Escherichia coli in Gushi chickens and its residue depletion following multiple oral administration. Poult Sci. 2024;103(4):103493. [Content Brief]
[2]. Tian E, et al. Population pharmacokinetics for danofloxacin in the intestinal contents of healthy and infected chickens. J Vet Pharmacol Ther. 2019;42(5):556-563. [Content Brief]
[3].
Yang Y, et al. Susceptibility breakpoint for Danofloxacin against swine Escherichia coli. BMC Vet Res. 2019 Feb 4;15(1):51.
[Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / 1 M NaOH | 1 mM | 2.7981 mL | 13.9907 mL | 27.9814 mL | 69.9535 mL |
| 5 mM | 0.5596 mL | 2.7981 mL | 5.5963 mL | 13.9907 mL | |
| 1 M NaOH | 10 mM | 0.2798 mL | 1.3991 mL | 2.7981 mL | 6.9954 mL |
| 15 mM | 0.1865 mL | 0.9327 mL | 1.8654 mL | 4.6636 mL | |
| 20 mM | 0.1399 mL | 0.6995 mL | 1.3991 mL | 3.4977 mL | |
| 25 mM | 0.1119 mL | 0.5596 mL | 1.1193 mL | 2.7981 mL | |
| 30 mM | 0.0933 mL | 0.4664 mL | 0.9327 mL | 2.3318 mL | |
| 40 mM | 0.0700 mL | 0.3498 mL | 0.6995 mL | 1.7488 mL | |
| 50 mM | 0.0560 mL | 0.2798 mL | 0.5596 mL | 1.3991 mL | |
| 60 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1659 mL | |
| 80 mM | 0.0350 mL | 0.1749 mL | 0.3498 mL | 0.8744 mL | |
| 100 mM | 0.0280 mL | 0.1399 mL | 0.2798 mL | 0.6995 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Danofloxacin 関連分類
HY-W011117 関連分類
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