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製品番号: HY-P99843A

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Datopotamab (powder)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Datopotamab (powder) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab (powder) can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab (powder) can be used in the study of triple negative breast cancer and non-small cell lung cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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Please store the product under the recommended conditions in the Certificate of Analysis.

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (2)
純度とドキュメンテーション
参考文献
Calculators
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関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

TROP2

体外実験

Datopotamab deruxtecan (Dato-DXd; 100 μg/mL) binds specifically to TROP2 and was internalized into tumor cells followed by intracellular trafficking to lysosome and Deruxtecan release, which induced DNA damage and apoptosis in TROP2-expressing tumor cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab powder deruxtecan in rats and cynomolgus monkeys are acceptable^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

SMILES

[Datopotamab (powder)]
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Cell Rep

Integrative genomic identification of therapeutic targets for pancreatic cancer. [Abstract]

2025 Aug 21;44(9):116191. PMID: 40848256

Datopotamab (powder) purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Aug 21;44(9):116191. [Abstract]

Zolbetuximab (0.01-100 nM). Dose-response curves of PDAC organoids in cell surface target-specific cytoablation assay. Data are representative of three biological replicates and are shown as mean ± SD.
Mol Carcinog

Targeting TROP2 and Exploiting AUNIP as a Determinant of ADC Cytotoxicity and Chemosensitivity in HNSCC and ESCA Cancers. [Abstract]

2026 May 7. PMID: 42096614

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Okajima D, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Dec;20(12):2329-2340. [Content Brief]

[2]. Daisuke Okajima, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Aug 19. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Datopotamab (powder)

2 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (2)
純度とドキュメンテーション
参考文献

1/16

Datopotamab (powder) purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Aug 21;44(9):116191. [Abstract]

Customer Validation
Zolbetuximab (0.01-100 nM). Dose-response curves of PDAC organoids in cell surface target-specific cytoablation assay. Data are representative of three biological replicates and are shown as mean ± SD.
1/16

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Datopotamab (powder)

MedChemExpress（MCE）の使用を引用している文献 Datopotamab (powder)

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Datopotamab (powder) 関連分類

HY-P99843A 関連分類