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Etaracizumab

(別名: LM609; MEDI-522)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Etaracizumab (LM 609) is an αvβ3 integrin IgG mAb. Etaracizumab is developed to target αvβ3+ cancer cells via NK cell-mediated cytotoxicity. Etaracizumab sterically hinders access of large ligands to the RGD-binding pocket, without obstructing it. Etaracizumab decreases p-Akt in vitro. Etaracizumab can decrease cancer proliferation and invasion. Etaracizumab induces tumor cell apoptosis, and inhibition ofαvβ3-mediated cell adhesion, endothelial cell migration and osteoclast-mediated bone resorption. Etaracizumab can be studied in anti-tumor research against cancers such as ovarian cancer, metastatic melanoma as well as advanced solid tumors. Recommend Isotype Control: Human IgG1 kappa, Isotype Control (HY-P99001).

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  • 純度: 99.81%
  • CAS 番号: 892553-42-3
  • 分子量:146.64 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Etaracizumab
  • Experimental Validation Results for Etaracizumab
  • Experimental Validation Results for Etaracizumab
  • Etaracizumab Chemical Structure
    Etaracizumab 構造式
CAS 番号: 892553-42-3
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最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells labeling Etaracizumab (HY-P99291, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized Human Integrin αVβ3, His Tag&Tag Free can bind Etaracizumab. The EC50 for this effect is 6.778 ng/mL.

  • Etaracizumab Chemical Structure
    1/16
  • Etaracizumab
  • Flow cytometric analysis of 1X106 HUVEC cells labeling Etaracizumab (HY-P99291, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized Human Integrin αVβ3, His Tag&Tag Free can bind Etaracizumab. The EC50 for this effect is 6.778 ng/mL.