C1QB - complement C1q B chain Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 713

About C1QB

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,653,236-22,661,637 (from NCBI)

This gene has 13 transcripts (splice variants), 145 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 482.2), lymph node (RPKM 181.6) and 15 other tissues.

Summary

This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum Complement System. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with Lupus Erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]

C1QB Products (3)

mRNA	Protein	Name
NM_000491.5	NP_000482.3	complement C1q subcomponent subunit B isoform 1 precursor
NM_001371184.3	NP_001358113.2	complement C1q subcomponent subunit B isoform 2 precursor
NM_001378156.1	NP_001365085.1	complement C1q subcomponent subunit B isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	7240	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in complement activation, classical pathway	IDA IDA: Inferred from direct assay	29449492	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of complement component C1q complex	IPI IPI: Inferred from physical interaction	29449492	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	18250442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QB Protein Structure

Collagen

C1q

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
complement C1q subcomponent subunit B	complement C1q chain B

C1QB Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	C1QB	P02746	Q07021-PRO_0000018590	Homo sapiens	Q07021-PRO_0000018590	ELISA	28018340
Intra	C1QB	P02746	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	C1QB	P02746	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	C1QB	P02746	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C1QB Proteins

製品番号	製品名	アクセッション番号	純度
HY-P75464	C1QB Protein, Human (sf9, His)	P02746 (Q28-A253)	≥ 90%, as determined by reducing SDS-PAGE.

C1QB 抗体

製品番号	製品名	アプリケーション	反応性
HY-P81889	C1QB Antibody (YA1634)	WB, IHC-P, ICC/IF	Human

関連疾患

Diseases	Alias
C1q Deficiency	C1QD Complement Component C1q Deficiency
Immunodeficiency Due To A Classical Component Pathway Complement Deficiency	Immunodeficiency Due To C1, C4, Or C2 Component Complement Deficiency Immunodeficiency Due To An Early Component Of Complement Deficiency
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Glomerulonephritis	Bright'S Disease
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS01719	C1QB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18604	C1qb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25089	C1qb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	C1QB	MGD	MGI:88224
Canis familiaris	C1QB	VGNC	VGNC:38577
Macaca mulatta	C1QB	VGNC	VGNC:106331
Felis catus	C1QB	VGNC	VGNC:60220
Rattus norvegicus	C1QB	RGD	RGD:2229
Bos taurus	C1QB	VGNC	VGNC:26617
Others	C1QB	NCBI