HDAC-IN-34
HDAC-IN-34 (compound 27) is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 μM for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 μM.
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- CAS 番号: 2857097-33-5
- 分子式: C24H26N6O3
- 分子量:446.50
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
|
HDAC1 0.022 ± 0. μM (IC50) |
HDAC6 0.45 ± 0.0 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human A549 cells
Antiproliferative activity against human A549 cells
|
[PMID: 37875056] |
| HCT-116 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HCT-116 cells
Antiproliferative activity against human HCT-116 cells
|
[PMID: 37875056] |
| HepG2 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
|
[PMID: 37875056] |
| HT-29 | IC50 |
1.41 μM
Compound: 25
|
Antiproliferative activity against human HT-29 cells
Antiproliferative activity against human HT-29 cells
|
[PMID: 37875056] |
| L02 | IC50 |
11.28 μM
Compound: 25
|
Cytotoxicity against human L02 cells
Cytotoxicity against human L02 cells
|
[PMID: 37875056] |
| NCM460 | IC50 |
18.47 μM
Compound: 25
|
Cytotoxicity against human NCM460 cells
Cytotoxicity against human NCM460 cells
|
[PMID: 37875056] |
化学情報
-
CAS 番号 2857097-33-5
-
分子量 446.50
-
分子式 C24H26N6O3
-
SMILES
COC1=CC2=C(C3=C(N2CC4CCN(CC4)C5=NC=C(C=N5)C(NO)=O)C(C)=NC=C3)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)