country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-178116

Copy Link Print Information

HER2-IN-23

HER2-IN-23 is a selective HER2 inhibitor. HER2-IN-23 reduces in total HER2 expression rather than in phosphorylated HER2 (p-HER2). HER2-IN-23 reduces cyclin D1 level and stimulates PARP cleavage. HER2-IN-23 can be used for the study of HER2-positive breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₂H₁₆ClFO₄
分子量:398.81

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

HER2-IN-23 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

生物活性

製品説明

EGFR アイソフォーム固有の製品をすべて表示 :

PARP アイソフォーム固有の製品をすべて表示 :

体外実験

HER2-IN-23 (Compound 4o) (0.4-25 μM, 72 h) shows moderate antiproliferative activity against HER2-positive cells (such as BT474 (IC₅₀ = 10.5 μM), A431 (IC₅₀ = 9.9 μM), and HCC1954 (IC₅₀ = 8.5 μM)), but exhibits lower activity against HER2-negative cells (such as MDA-MB-231 (IC₅₀ = 19.7 μM) and MCF7 (IC₅₀ = 12.8 μM))^[1].
HER2-IN-23 (1 μM) inhibits HER2 kinase by 84% at a concentration of 1 μM, while showing low or no inhibition against other kinases (such as EGFR, HER4, IGF1R, etc.)^[1].
HER2-IN-23 (10 μM, 24 h) significantly reduces total HER2 expression in A431 cells, but phosphorylated HER2 (p-HER2) shows no significant change; simultaneously, cyclin D1 expression is almost completely inhibited, and an increase in PARP cleavage is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

A431 cells
Concentration:

10 μM
Incubation Time:

24 h
Result:

Significantly reduced total HER2 expression in A431 cells, but phosphorylated HER2 (p-HER2) showed no significant change; simultaneously, cyclin D1 expression was almost completely inhibited, and an increase in PARP cleavage was observed.

化学情報

分子量 398.81
分子式 C₂₂H₁₆ClFO₄
SMILES

O=C1C(C2=CC=C(OCC3=CC=CC(F)=C3)C(Cl)=C2)=COC4=C1C(CCC4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Rubinov DB, et al. A facile method for the preparation of 7,8-dihydro-4H-chromene-4,5(6H)-diones as non-aromatic cycle A analogs of isoflavones and their evaluation as antiproliferative agents. Bioorg Chem. 2025 Oct;165:108960. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

HER2-IN-23

EGFR アイソフォーム固有の製品をすべて表示

PARP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HER2-IN-23 関連分類

HY-178116 関連分類