製品番号: HY-122308

Militarine

(別名: ミリタリン)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.94%
CAS 番号: 58139-23-4
分子式: C₃₄H₄₆O₁₇
分子量:726.72

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Militarine 構造式

CAS 番号: 58139-23-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

COX-2

IL-6

IL-1β

NF-κB アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

COX アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	>10 μM Compound: 43	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction	[PMID: 27525452]
Neutrophil	IC₅₀	>10 μM Compound: 43	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal	[PMID: 27525452]

体外実験

Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of lettuce (Lactuca sativa L. cv. Great Lakes 366), with an EC₅₀ value of 0.28 mM for radicles and 1.03 mM for hypocotyls^[1].
Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of Lolium multiflorum Lam., with an EC₅₀ value of 0.43 mM for radicles and 1.18 mM for hypocotyls^[1].
Militarine (58 h) inhibits the elongation of radicles and hypocotyls in Phleum pratense L. seedlings, with corresponding EC₅₀ values of 0.32 mM and 0.82 mM for radicles and hypocotyls, respectively^[1].
Militarine (1.25-60 μg/mL; 24 h) reduces the viability of A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the secretion levels of IL-6 and TNF-α in A549 cells exposed to PM_2.5^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the mRNA expression of IL-6, TNF-α, IL-1β and COX-2, and reduces the accumulation level of ROS in PM_2.5-exposed A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the apoptosis level of A549 cells after PM_2.5 exposure, and inhibits cell migration and invasion^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the activation of the NF-κB pathway by reducing the phosphorylation levels of IKKβ, IκBα and NF-κBp65 in A549 cells exposed to PM_2.5; in addition, 5 and 10 μg/mL Militarine reduces the COX-2 protein level in PM_2.5-exposed cells after 18 h of exposure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

human lung alveolar epithelial A549 cells
Concentration:

1.25, 2.5, 5, 10, 20, 40, 60 μg/mL
Incubation Time:

24 h
Result:

Exerted a marked inhibitory effect on A549 cell viability at 20, 40 and 60 μg/mL.

ELISA Assay^[2]

Cell Line:

PM₂.₅-exposed human lung alveolar epithelial A549 cells
Concentration:

1.25, 2.5, 5, 10 μg/mL
Incubation Time:

2 h (pretreatment); 18 h (PM₂.₅ exposure)
Result:

Significantly decreased IL-6 content relative to the PM₂.₅-only group at all tested concentrations.
Significantly decreased TNF-α content relative to the PM₂.₅-only group at 5 and 10 μg/mL.

化学情報

CAS 番号 58139-23-4
性状 Solid
分子量 726.72
分子式 C₃₄H₄₆O₁₇
Color White to light yellow
SMILES

O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@H]1O)CO)OC(C=C2)=CC=C2COC([C@](CC(C)C)(O)CC(OCC(C=C3)=CC=C3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO)=O)=O
別名

ミリタリン
Structure Classification
- Phenols
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Metabolism

Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis. [Abstract]

2026 Jul:180:156622. PMID: 41997496

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (137.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (68.80 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3760 mL

6.8802 mL

13.7605 mL

5 mM

0.2752 mL

1.3760 mL

2.7521 mL

10 mM

0.1376 mL

0.6880 mL

1.3760 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sakuno E, et al. Contribution of militarine and dactylorhin A to the plant growth‐inhibitory activity of a weed‐suppressing orchid, Bletilla striata. Weed biology and management, 2010, 10(3): 202-207.

[2]. Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM_2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021;896:173931. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.3760 mL	6.8802 mL	13.7605 mL	34.4011 mL
	5 mM	0.2752 mL	1.3760 mL	2.7521 mL	6.8802 mL
	10 mM	0.1376 mL	0.6880 mL	1.3760 mL	3.4401 mL
	15 mM	0.0917 mL	0.4587 mL	0.9174 mL	2.2934 mL
	20 mM	0.0688 mL	0.3440 mL	0.6880 mL	1.7201 mL
	25 mM	0.0550 mL	0.2752 mL	0.5504 mL	1.3760 mL
	30 mM	0.0459 mL	0.2293 mL	0.4587 mL	1.1467 mL
	40 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8600 mL
	50 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6880 mL
	60 mM	0.0229 mL	0.1147 mL	0.2293 mL	0.5734 mL
DMSO	80 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.4300 mL
DMSO	100 mM	0.0138 mL	0.0688 mL	0.1376 mL	0.3440 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Militarine

1 Cited Publications

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Militarine

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MedChemExpress（MCE）の使用を引用している文献 Militarine

NF-κB アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

COX アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Militarine 関連分類

HY-122308 関連分類