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United States

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製品番号: HY-187673

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Parconazole

Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 61400-59-7
分子式: C₁₇H₁₆Cl₂N₂O₃
分子量:367.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Parconazole 構造式

CAS 番号: 61400-59-7

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Parconazole (0.01-100 mg/L; 30-2000 nM) inhibits the in vitro growth of diverse fungi, with 50% inhibition of Candida albicans growth occurring at 30 nM in CYG medium and complete inhibition of dermatophyte growth occurring at 1-10 mg/L in Sabouraud liquid medium^[1].
Parconazole selectively inhibits Candida albicans cytochrome P450, with far higher affinity for the fungal enzyme than for three different mammalian cytochrome P450 isoforms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Parconazole (13 mg/kg; p.o.; single administration) reaches a peak plasma concentration of 2.28 mg/L at 2 h in guinea fowl, and is mainly enriched in the crop and skin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

guinea fowl^[1]
Dosage:

13 mg/kg
Administration:

p.o.; single administration
Result:

Reached a peak plasma concentration of 2.28 mg/L at 2 h, and is mainly enriched in the crop and skin.

化学情報

CAS 番号 61400-59-7
分子量 367.23
分子式 C₁₇H₁₆Cl₂N₂O₃
SMILES

C([C@]1(O[C@@H](COCC#C)CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=CN=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Vanden Bossche H, et al. Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects. Journal of veterinary pharmacology and therapeutics. 2003 Feb;26(1):5-29.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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