61400-59-7
Chemical Structure
Parconazole
- CAS No.: 61400-59-7
- Formula:C17H16Cl2N2O3
- Molecular Weight:367.23
IUPAC Name: 1-(((2R,4S)-2-(2,4-dichlorophenyl)-4-((prop-2-yn-1-yloxy)methyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole
InChIKey: SWKACZZMDOWWGU-YOEHRIQHSA-N
SMILES: C([C@]1(O[C@@H](COCC#C)CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=CN=C3
Biological Activity: Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections[1].
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Parconazole | Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections. | |||||||||||||||||||||
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