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Cat. No.: HY-187673

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Parconazole

Parconazole is an orally active imidazole derivative and antifungal (fungal) agent. Parconazole inhibits sterol 14α-demethylase (CYP51) and Δ22-desaturase (CYP61), disrupting fungal Ergosterol (HY-N0181) biosynthesis by reducing the availability of ergosterol and promoting the accumulation of 14-methyl sterols. Parconazole exhibits in vitro antifungal activity against dermatophytes, Candida species, Blastomyces dermatitidis yeast, piedraia, and actinomycetes. Parconazole can be used in the study of fungal infections.

For research use only. We do not sell to patients.

CAS No.: 61400-59-7
Formula: C₁₇H₁₆Cl₂N₂O₃
Molecular Weight:367.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Parconazole Chemical Structure

CAS No.: 61400-59-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Parconazole (0.01-100 mg/L; 30-2000 nM) inhibits the in vitro growth of diverse fungi, with 50% inhibition of Candida albicans growth occurring at 30 nM in CYG medium and complete inhibition of dermatophyte growth occurring at 1-10 mg/L in Sabouraud liquid medium^[1].
Parconazole selectively inhibits Candida albicans cytochrome P450, with far higher affinity for the fungal enzyme than for three different mammalian cytochrome P450 isoforms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parconazole (13 mg/kg; p.o.; single administration) reaches a peak plasma concentration of 2.28 mg/L at 2 h in guinea fowl, and is mainly enriched in the crop and skin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

guinea fowl^[1]
Dosage:

13 mg/kg
Administration:

p.o.; single administration
Result:

Reached a peak plasma concentration of 2.28 mg/L at 2 h, and is mainly enriched in the crop and skin.

Chemical Information

CAS No. 61400-59-7
Molecular Weight 367.23
Formula C₁₇H₁₆Cl₂N₂O₃
SMILES

C([C@]1(O[C@@H](COCC#C)CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=CN=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vanden Bossche H, et al. Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects. Journal of veterinary pharmacology and therapeutics. 2003 Feb;26(1):5-29.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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