78 Results for "

Pgc

" in MedChemExpress (MCE) Product Catalog:

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SR-18292

66 Publications Verification

製品番号: HY-101491

CAS 番号: 2095432-55-4

純度: 99.87%

Target:

PGC-1α Autophagy

研究分野:

Metabolic Disease

SR-18292 is a PPAR gamma coactivator-1α (PGC-1α) inhibitor, which increases PGC-1α acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes.

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ZLN005

51 Cited Publications

製品番号: HY-17538

CAS 番号: 49671-76-3

Target:

PGC-1α Autophagy

研究分野:

Metabolic Disease

ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) .

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D-Mannitol

15 Cited Publications

製品番号: HY-N0378

CAS 番号: 69-65-8

別名: Mannitol; Mannite

Category:

天然物 other families Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Environmental Pollutants Endogenous Metabolite Apoptosis PGC-1α PKA Adrenergic Receptor

D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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Isorhapontigenin

4 Cited Publications

製品番号: HY-N2593

CAS 番号: 32507-66-7

Category:

Stilbenes Gnetum cleistostachyum C. Y. Cheng Gnetaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .

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MOTS-c (human)

1 Cited Publications

製品番号: HY-P2048

CAS 番号: 1627580-64-6

Target:

Apoptosis GLUT AMPK

研究分野:

Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

MOTS-c (human) is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

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(+)-Medioresinol

1 Cited Publications

製品番号: HY-N3307

CAS 番号: 40957-99-1

Category:

Cardiovascular Disease Neurological Disease Oleaceae Fraxinus mandshurica Rupr. Phenols Polyphenols Plants Disease Research Fields

Target:

Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis MMP Interleukin Related PI3K Akt mTOR PPAR PGC-1α Pyroptosis

(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .

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MOTS-c(human) acetate

1 Cited Publications

製品番号: HY-P2048A

Target:

AMPK GLUT

研究分野:

Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

MOTS-c (human) acetate is a blood-brain barrier-penetrating, mitochondrial-derived peptide that modulates the AMPK/PGC-1α pathway to enhance insulin sensitivity. MOTS-c (human) acetate inhibits the folate cycle and de novo purine synthesis, increases AICAR levels to activate AMPK, and then regulates the Nrf2/Keap1 antioxidant pathway and inhibits the NF-κB inflammatory pathway, while promoting mitochondrial biogenesis and energy metabolism. MOTS-c (human) acetate has the effects of improving glucose and lipid metabolism, anti-oxidative stress, anti-inflammatory and neuroprotection, and can be used in the study of type 2 diabetes, traumatic brain injury, inflammatory diseases and aging-related metabolic disorders .

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ERRα ligand 2

1 Cited Publications

製品番号: HY-126351

CAS 番号: 2306388-57-6

純度: 99.36%

Target:

Ligands for Target Protein for PROTAC Estrogen Receptor/ERR

研究分野:

Cancer

ERRα ligand 2 is a ERRα ligand with a target IC₅₀ of 5.67 nM. PROTAC ERRα ligand 2 blocks the protein-protein interaction between ERRα and PGC-1α. PROTAC ERRα ligand 2 can be used for synthesis of PROTACs .

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PGC1 alpha Antibody

1 Cited Publications

製品番号: HY-P80783

別名: PPARGC1A; LEM6; Pgc1; Pgc1A; PPARGC1; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Pgc-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6

Host:

Rabbit

Application:

Reactivity:

Human, Mouse, Rat

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PGC1 alpha Antibody (YA7180)

1 Cited Publications

製品番号: HY-P80783A

Host:

Rabbit

Application:

Reactivity:

Human, Mouse, Rat

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Schizophyllan

製品番号: HY-165126

CAS 番号: 9050-67-3

別名: SPG

Target:

C-type Lectin-like Receptors (CTLRs) Endogenous Metabolite Sirtuin JNK p38 MAPK PPAR AP-1

研究分野:

Infection Metabolic Disease Inflammation/Immunology Cancer

Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune. Schizophyllan improves mitochondrial function and protects against metabolic liver injury by activating the SIRT3 pathway. Schizophyllan inhibits osteoclastogenesis and promotes osteoblast differentiation by suppressing the phosphorylation of JNK/p38, as well as downregulating PGC1β/PPARγ, c-Fos and NFATc1. Recognized via Dectin-1, schizophyllan enables precise delivery of oligonucleotide drugs and antigens to antigen-presenting cells, thus holding great potential in the treatment of inflammatory diseases and vaccine development .

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Schisanhenol

製品番号: HY-N0859

CAS 番号: 69363-14-0

別名: Schizanhenol; Gomisin-K3

Category:

Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:

UGT Cholinesterase (ChE) Tau Protein SOD Sirtuin

Schisanhenol (Schizanhenol), a lignan, is an orally active antioxidant. Schisanhenol reduces AChE activity, increases SIRT1 and PGC-1α expression, and decreases phosphorylated Tau (Ser 396) levels. Schisanhenol increases SOD and glutathione peroxidase activity, decreases malondialdehyde (MDA) content, and inhibits UGT2B7 activitY. Schisanhenol attenuates ox-LDL-induced apoptosis, intracellular reactive oxygen species generation, and cytotoxicity in endothelial cells. Schisanhenol inhibits LDL oxidation, brain mitochondrial and membrane peroxidative damage, and brain mitochondrial swelling and disintegration. Schisanhenol can be used for the research of Alzheimer’s disease, atherosclerosis, brain ischemia, and age-related brain deterioration .

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D-Arabitol

製品番号: HY-N3686

CAS 番号: 488-82-4

Category:

Endogenous metabolite Saccharides

Target:

AMPK PGC-1α

D-Arabitol is an orally active D-enantiomer of arabitol. D-Arabitol modulates the composition of gut microbiota, increases short-chain fatty acids, and promotes AMPK-PGC-1α-related browning of white adipose tissue. D-Arabitol improves weight gain, fat accumulation, insulin resistance, lipid deposition and inflammatory responses. D-Arabitol serves as the sole carbon/energy source for Bacillus methanolicus MGA3, a strain that can co-utilize it with mannitol. D-Arabitol is applicable to obesity-related research .

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D-Mannitol (Standard)

製品番号: HY-N0378R

CAS 番号: 69-65-8

別名: Mannitol(Standard); Mannite (Standard)

Category:

天然物 other families Microorganisms Metabolic Disease Plants Endogenous metabolite Disease Research Fields Sweeteners Food Research

Target:

Reference Standards Endogenous Metabolite Apoptosis PGC-1α Adrenergic Receptor PKA

D-Mannitol (Standard) is the analytical standard of D-Mannitol (HY-N0378). This product is intended for research and analytical applications. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells . D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed .

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Perfluorotetradecanoic acid

製品番号: HY-W073128

CAS 番号: 376-06-7

別名: PFTeDA

Target:

PPAR Apoptosis PGC-1α AMPK Akt mTOR Reactive Oxygen Species (ROS)

研究分野:

Endocrinology

Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a K_d value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats .

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NSC 90469

製品番号: HY-114557

CAS 番号: 1041-01-6

純度: 99.38%

別名: 3,5-Diiodo-L-thyronine

Category:

Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:

JNK NF-κB Sirtuin PGC-1α COX TGF-β Receptor Collagen

NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .

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ERRα antagonist-1

製品番号: HY-113960

CAS 番号: 1072145-33-5

純度: 99.71%

Target:

Estrogen Receptor/ERR

研究分野:

Cancer

ERRα antagonist-1 (Compound A) is a selective and high affinity agonist for estrogen-related receptor α (ERRα). ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC₅₀ values are 170 nM and 180 nM, respectively .

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Phoenixin-20

製品番号: HY-P5763

CAS 番号: 1415039-77-8

別名: PNX-20

Target:

Epigenetic Reader Domain PGC-1α

研究分野:

Neurological Disease

Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect .

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Mogroside VI B

製品番号: HY-N7439

CAS 番号: 2149606-17-5

Category:

Triterpenes Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields

Target:

PGC-1α

Mogroside VI B, a cucurbitane glucoside, separated from the crude extract of Siraitia grosvenorii. Mogroside VI B shows effect on activating PGC-1α transcription .

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AdipoR agonist 1

製品番号: HY-130479

CAS 番号: 949745-75-9

純度: ≥98.0%

Target:

Adiponectin Receptor PPAR PGC-1α Sirtuin AMPK

研究分野:

Metabolic Disease

AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research .

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