Perfluorotetradecanoic acid
Perfluorotetradecanoic acid (PFTeDA) is an orally active perfluoroalkyl substance. Perfluorotetradecanoic acid directly binds to the ligand-binding domain of purified hPPARγ, with a Kd value of 157.8 μM. Perfluorotetradecanoic acid significantly reduces the activity of the SIRT1/PGC1α and AMPK signaling pathways while stimulating the activity of the AKT1/mTOR signaling pathway. Perfluorotetradecanoic acid significantly upregulates the expression of corticosterone biosynthesis genes. Perfluorotetradecanoic acid increases ROS levels and promotes Apoptosis. Perfluorotetradecanoic acid impairs Leydig cell function and male reproductive endocrine function in adult male rats.
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- 純度: 98.0%
- CAS 番号: 376-06-7
- 分子式: C14HF27O2
- 分子量:714.11
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Akt1 |
hPPARγ 157.8 μM (Kd) |
Perfluorotetradecanoic acid (1-50 μM; 24 h) significantly inhibits testosterone secretion in primary rat Leydig cells[1].
Perfluorotetradecanoic acid (10-50 μM; 24 h) significantly increases the level of ROS in primary rat Leydig cells, with a stronger effect observed at 50 μM[1].
Perfluorotetradecanoic acid (50 μM; 24 h) significantly increases the apoptosis rate of primary rat Leydig cells[1].
Perfluorotetradecanoic acid directly binds to the purified ligand-binding domain of hPPARγ, with a Kd value of 157.8 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Perfluorotetradecanoic acid (1-10 mg/kg; i.g.; daily; 28 days) disrupts adrenal cortex function in adult male rats, with the 10 mg/kg dose driving the most robust effects: increased corticosterone biosynthesis via zona fasciculata hyperplasia and upregulated steroidogenic gene/protein expression, decreased aldosterone biosynthesis via downregulated Cyp11b2 expression, impaired antioxidant defense, and altered SIRT1/PGC1α, AMPK, and AKT1/mTOR signaling[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 60 days old at start of treatment)[1]
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Dosage:1 mg/kg/day; 5 mg/kg/day; 10 mg/kg/day
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Administration:i.g.; daily; 28 days
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Result:Significantly reduced serum testosterone levels at all doses.
Significantly increased serum follicle-stimulating hormone levels at all doses.
Significantly increased serum luteinizing hormone levels at 10 mg/kg/day.
Significantly reduced sperm count in the cauda epididymis at all doses.
Significantly reduced number of CYP11A1-positive Leydig cells (normalized to Sertoli cell number) at 10 mg/kg/day.
Significantly increased percentage of apoptotic Leydig cells at 10 mg/kg/day.
Significantly increased number of apoptotic germ cells per seminiferous cord at all doses.
化学情報
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CAS 番号 376-06-7
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性状 Solid
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分子量 714.11
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分子式 C14HF27O2
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Color White to off-white
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SMILES
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)F)F)F)O
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別名
PFTeDA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (272 KB)
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- Portuguese - PT (557 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tang Y, et al. Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis. Environ Toxicol. 2022;37(7):1790-1802. [Content Brief]
[2]. Zhang L, et al. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ. Toxicol Appl Pharmacol. 2014;279(3):275-283. [Content Brief]
[3]. Ying Y, et al. Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production. Environ Toxicol. 2024;39(5):2610-2622. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Perfluorotetradecanoic acid 関連分類
HY-W073128 関連分類
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