1415039-77-8
Chemical Structure
Phoenixin-20
Synonym(s): PNX-20
- CAS No.: 1415039-77-8
- Formula:C101H153N25O29
- Molecular Weight:2181.45
InChIKey: IQRYUACIXWOSOA-PUGGNXOESA-N
SMILES: O=C(NCC(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Biological Activity: Phoenixin-20 (PNX-20) is a neuropeptide that activates GPR173. Phoenixin-20 inhibits LPS-induced TLR-4/MyD88/NF-κB signaling, pro-inflammatory cytokines, adhesion molecules, MMPs, and cytotoxicity. Phoenixin-20 increases SIRT1 and inhibits NLRP3/ASC/caspase-1, oxidative stress, and IL-1β/IL-18. Phoenixin-20 alleviates ox-LDL-induced endothelial dysfunction, monocyte adhesion, adhesion molecules, cytokines, NADPH oxidase/NOX-4, and ROS. Phoenixin-20 promotes GPR173/STAT6-mediated anti-inflammatory polarization of microglia and neuroprotection. Phoenixin-20 can be used in research on dental pulp infection, pulmonary arterial hypertension, atherosclerosis, neuroinflammation, anxiety, and neurodegenerative diseases[1][2][3][4][5][6][7][8][9][10].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phoenixin-20 | 99.66% | Phoenixin-20 (PNX-20) is a neuropeptide that activates GPR173. Phoenixin-20 inhibits LPS-induced TLR-4/MyD88/NF-κB signaling, pro-inflammatory cytokines, adhesion molecules, MMPs, and cytotoxicity. Phoenixin-20 increases SIRT1 and inhibits NLRP3/ASC/caspase-1, oxidative stress, and IL-1β/IL-18. Phoenixin-20 alleviates ox-LDL-induced endothelial dysfunction, monocyte adhesion, adhesion molecules, cytokines, NADPH oxidase/NOX-4, and ROS. Phoenixin-20 promotes GPR173/STAT6-mediated anti-inflammatory polarization of microglia and neuroprotection. Phoenixin-20 can be used in research on dental pulp infection, pulmonary arterial hypertension, atherosclerosis, neuroinflammation, anxiety, and neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Sun G, et al. Phoenixin-20 suppresses lipopolysaccharide-induced inflammation in dental pulp cells. Chemico-biological interactions. 2020 Feb 25;318:108971.
- [2]. Chai Y, et al. Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress. Aging. 2024 Mar 19;16(6):5027-5037.
- [3]. Wei X, et al. Phoenixin-20 Prevents ox-LDL-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs): A Protective Implication in Atherosclerosis. ACS chemical neuroscience. 2021 Mar 17;12(6):990-997.
- [4]. Xie T, et al. High-fat diet-induced obesity accelerates puberty in male rats through SMIM20/phoenixin upregulation. Frontiers in endocrinology. 2025;16:1711374.
- [5]. Cowan A, et al. Phoenixin: A candidate pruritogen in the mouse. Neuroscience. 2015 Dec 03;310:541-8.
- [6]. Zeng X, et al. Phoenixin-20 Ameliorates Lipopolysaccharide-Induced Activation of Microglial NLRP3 Inflammasome. Neurotoxicity research. 2020 Oct;38(3):785-792.
- [7]. Wang S, et al. Phoenixin-20 ameliorates brain infarction by promoting microglia M2 polarization in an ischemic stroke model. Metabolic brain disease. 2022 Jun;37(5):1517-1526.
- [8]. Rajeswari JJ, et al. Phoenixin-20 suppresses food intake, modulates glucoregulatory enzymes, and enhances glycolysis in zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 May 01;318(5):R917-R928.
- [9]. Rajeswari JJ, et al. Phoenixin-20 Stimulates mRNAs Encoding Hypothalamo-Pituitary-Gonadal Hormones, is Pro-Vitellogenic, and Promotes Oocyte Maturation in Zebrafish. Scientific reports. 2020 Apr 14;10(1):6264. [Content Brief]
- [10]. Yang Y, et al. Phoenixin 20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Journal of molecular histology. 2020 Apr;51(2):173-181. [Content Brief]
