U-19052
U-19052 is a selective competitive peptidoleukotriene D/E receptor antagonist. U-19052 acts as a reversible antagonist that not affecting responses to non-leukotriene agonists. U-19052 does not exhibit agonist activity or induce contraction in guinea pig tracheal or ileal strips. U-19052 is a leukotriene antagonist developed by modifying leukotriene chemical structure. U-19052 can be used for the research of allergic asthma and hypersensitivity diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 112682-32-3
- 分子式: C31H42O6S
- 分子量:542.73
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Leukotriene Receptor アイソフォーム固有の製品をすべて表示
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生物活性
U-19052 (10 μM; 30 min) acts as a selective, competitive antagonist of peptidoleukotriene receptors on guinea pig tracheal strips, with a pKB of 6.43 against LTD4, 5.80 against LTE4, and 5.54 against LTC4[1].
U-19052 (10 μM; 10 min) inhibits LTE4-induced contraction of guinea pig tracheal strips without exhibiting agonist activity[1].
U-19052 (10 μM; 60 min) acts as a competitive antagonist of peptidoleukotriene receptors on guinea pig ileal segments, with a pKB of 7.25 against LTD4 and 7.17 against LTE4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 112682-32-3
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分子量 542.73
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分子式 C31H42O6S
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SMILES
CCCCCCCC(C=C1)=CC=C1C/C=C\[C@H]([C@@H](O)CCCC(O)=O)SCC2=C(C=C(C=C2)C(O)=O)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
U-19052 関連分類
HY-182515 関連分類
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