country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

ARHGAP32 - Rho GTPase activating protein 32 Gene

Also Known as GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9743

About ARHGAP32

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:128,965,060-129,279,632 (from NCBI)

This gene has 9 transcripts (splice variants), 209 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues.

Summary

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]

ARHGAP32 Products (4)

mRNA	Protein	Name
NM_001142685.2	NP_001136157.1	rho GTPase-activating protein 32 isoform 1
NM_001378024.1	NP_001364953.1	rho GTPase-activating protein 32 isoform 3
NM_001378025.1	NP_001364954.1	rho GTPase-activating protein 32 isoform 4
NM_014715.4	NP_055530.2	rho GTPase-activating protein 32 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12788081	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP32 Protein Structure

SH3_9

RhoGAP

0
400
800
1200
1600
2000
2087 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 32	GAB-associated CDC42

ARHGAP32 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGAP32	A7KAX9	LHX2	Homo sapiens	P50458	Y2H Prey Pooling	32296183
Intra	ARHGAP32	A7KAX9	LHX2	Homo sapiens	P50458	Validated Y2H	32296183
Intra	ARHGAP32	A7KAX9	LHX2	Homo sapiens	P50458	Y2H Array	32296183
Intra	ARHGAP32	A7KAX9	SFN	Homo sapiens	P31947	TAP	15778465
Intra	ARHGAP32	A7KAX9	FYN	Homo sapiens	P06241	Y2H	12788081
Intra	ARHGAP32	A7KAX9	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	ARHGAP32	A7KAX9	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	ARHGAP32	A7KAX9	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	ARHGAP32	A7KAX9	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	ARHGAP32	A7KAX9	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	ARHGAP32	A7KAX9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	ARHGAP32	A7KAX9	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	ARHGAP32	A7KAX9	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Intra	ARHGAP32	A7KAX9	ABI2	Homo sapiens	Q9NYB9	Y2H Prey Pooling	25416956
Intra	ARHGAP32	A7KAX9	DZIP3	Homo sapiens	Q86Y13	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Subclavian Steal Syndrome	Subclavian Artery Stenosis Subclavian Steal Phenomenon Subclavian Steal Steno-Occlusive Disease Subclavian Steal
Jacobsen Syndrome	Chromosome 11q Deletion Syndrome Partial 11q Monosomy Syndrome Jacobsen Distal 11q Deletion Syndrome JBS 11q Partial Monosomy Syndrome Chromosome 11q Deletion 11q Deletion 11q Monosomy Deletion 11q Monosomy 11q Partial Monosomy 11q 11q Deletion Disorder 11q Deletion Syndrome 11q Terminal Deletion Disorder 11q- Deletion Syndrome 11q23 Deletion Disorder Jacobsen Thrombocytopenia 11q Terminal Deletion Syndrome Del(11)(Q23.3) Del(11)(Qter) Distal Deletion 11q Distal Monosomy 11q Monosomy 11qter Telomeric Deletion 11q Paris-Trousseau Thrombocytopenia
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Chromosome 17q23.1-Q23.2 Deletion Syndrome	17q23.1q23.2 Microdeletion Syndrome 17q23.1-Q23.2 Microdeletion Syndrome Del(17)(Q23.1q23.2) Monosomy 17q23.1q23.2 Monosomy 17q23.1-Q23.2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00931	ARHGAP32 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ARHGAP32	VGNC	VGNC:59889
Bos taurus	ARHGAP32	VGNC	VGNC:26090
Canis familiaris	ARHGAP32	VGNC	VGNC:38059
Rattus norvegicus	ARHGAP32	RGD	RGD:1305267
Macaca mulatta	ARHGAP32	VGNC	VGNC:69855
Mus musculus	ARHGAP32	MGD	MGI:2450166
Others	ARHGAP32	NCBI