aPKC-IN-2
Based on 1 Customer Validation
aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.80%
- CAS No.: 15854-08-7
- 화학식: C14H15NO2S
- 분자량:261.34
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Chemical Information
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CAS No. 15854-08-7
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Appearance Solid
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분자량 261.34
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화학식 C14H15NO2S
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Color Off-white to light yellow
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SMILES
O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 62.5 mg/mL (239.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8264 mL | 19.1322 mL | 38.2643 mL | 95.6608 mL |
| 5 mM | 0.7653 mL | 3.8264 mL | 7.6529 mL | 19.1322 mL | |
| 10 mM | 0.3826 mL | 1.9132 mL | 3.8264 mL | 9.5661 mL | |
| 15 mM | 0.2551 mL | 1.2755 mL | 2.5510 mL | 6.3774 mL | |
| 20 mM | 0.1913 mL | 0.9566 mL | 1.9132 mL | 4.7830 mL | |
| 25 mM | 0.1531 mL | 0.7653 mL | 1.5306 mL | 3.8264 mL | |
| 30 mM | 0.1275 mL | 0.6377 mL | 1.2755 mL | 3.1887 mL | |
| 40 mM | 0.0957 mL | 0.4783 mL | 0.9566 mL | 2.3915 mL | |
| 50 mM | 0.0765 mL | 0.3826 mL | 0.7653 mL | 1.9132 mL | |
| 60 mM | 0.0638 mL | 0.3189 mL | 0.6377 mL | 1.5943 mL | |
| 80 mM | 0.0478 mL | 0.2392 mL | 0.4783 mL | 1.1958 mL | |
| 100 mM | 0.0383 mL | 0.1913 mL | 0.3826 mL | 0.9566 mL |
aPKC-IN-2 Related Classifications
HY-W030338 Related Classifications
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