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Cat. No.: HY-182561

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Cgs 27830

Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs.

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CAS No.: 155485-56-6
화학식: C₃₂H₃₀N₄O₁₁
분자량:646.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cgs 27830 Chemical Structure

CAS No.: 155485-56-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All Endothelin Receptor Isoforms :

ET_A
ET_B

In Vivo

CGS 27830 (100 mcg/min; intrapulmonary infusion; 10 min) does not alter basal pulmonary vascular tone in late gestation fetal lambs but completely blocks big-ET-1-induced pulmonary vasoconstriction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Columbia-Rambouillet (mixed breed, late gestation 131 days)^[1]
Dosage:

100 mcg/min
Administration:

intrapulmonary infusion; 10 min
Result:

Did not alter baseline left pulmonary artery flow, mean pulmonary artery pressure, mean aortic pressure, left atrial pressure, pulmonary vascular resistance, heart rate, or blood gas parameters.
Blocked the big-ET-1-induced increase in pulmonary vascular resistance.
Blocked the big-ET-1-induced rise in mean pulmonary artery pressure.
Prevented changes in left pulmonary artery flow.

Chemical Information

CAS No. 155485-56-6
분자량 646.60
화학식 C₃₂H₃₀N₄O₁₁
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)OC(C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC([N+]([O-])=O)=CC=C4)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ivy DD, et al. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest. 1994;93(5):2141-2148. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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