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TMSB4X - thymosin beta 4 X-linked Gene

Also Known as FX; TB4X; PTMB4; TMSB4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7114

About TMSB4X

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,975,110-12,977,223 (from NCBI)

This gene has 4 transcripts (splice variants), 34 orthologues, 1 paralogue and is associated with 32 phenotypes. Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues.

Summary

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

TMSB4X Products (1)

mRNA	Protein	Name
NM_021109.4	NP_066932.1	thymosin beta-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin monomer binding	IDA IDA: Inferred from direct assay	1447300	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21106936	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17967441	GOA
enables protein sequestering activity	IMP IMP: Inferred from mutant phenotype	21343177	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive effect negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21343177	GOA
involved in negative regulation of hematopoietic stem cell differentiation	IDA IDA: Inferred from direct assay	7694679	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21343177	GOA
involved in positive regulation of ATP biosynthetic process	IDA IDA: Inferred from direct assay	21106936	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	21106936	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	21106936	GOA
involved in positive regulation of endothelial cell chemotaxis	IDA IDA: Inferred from direct assay	21106936	GOA
involved in positive regulation of proton-transporting ATP synthase activity, rotational mechanism	IDA IDA: Inferred from direct assay	21106936	GOA
involved in sequestering of actin monomers	IDA IDA: Inferred from direct assay	1447300	GOA
acts upstream of or within positive effect tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21343177	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21343177	GOA
located in cytosol	IDA IDA: Inferred from direct assay	1447300	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21343177	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMSB4X Protein Structure

Thymosin

0
44 a.a.

Protein Preferred Names	Protein Names
thymosin beta-4	prothymosin beta-4

TMSB4X Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	TMSB4X	P62328	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	TMSB4X	P62328	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	TMSB4X	P62328	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Validated Y2H	32296183
Intra	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	UHMK1	Homo sapiens	Q8TAS1-2	Y2H Array	32296183
Intra	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	TMSB4X	P62328	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	TMSB4X	P62328	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TMSB4X	P62328	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Bait CoIP	17967441
Intra	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Y2H	17967441
Intra	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Bait CoIP	20706999
Intra	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Anti Tag CoIP	20706999
Intra	TMSB4X	P62328	MLH1	Homo sapiens	P40692	Confocal	17967441
Intra	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	TMSB4X	P62328	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMSB4X Proteins

Cat. No.	상품명	Accession	Purity
HY-P72776	TMSB4X/Thymosin beta 4 Protein, Human	P62328 (S2-S44)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71930A	TMSB4X/Thymosin beta 4 Protein, Human (His)	P62328 (S2-S44)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Pulmonary Systemic Sclerosis	Lung Disease With Systemic Sclerosis Lung Involvement In Systemic Sclerosis
Invasive Malignant Thymoma	Infiltrating Thymoma Thymoma Malignant Invasive Invasive Thymoma And Thymic Carcinoma
Thymoma	Primary Thymic Epithelial Neoplasm Primary Thymic Epithelial Tumor Thymus Neoplasms
Lateral Myocardial Infarction
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Keratopathy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Malignant Iris Melanoma	Malignant Melanoma Of Iris Melanoma Of The Iris

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS14775	TMSB4X Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17930	Tmsb4x Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24400	Tmsb4x Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TMSB4X	MGD	MGI:99510
Rattus norvegicus	TMSB4X	RGD	RGD:621622