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Cat. No.: HY-N21582

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Gitogenin 3-O-lycotetroside

Gitogenin 3-O-lycotetroside is a steroidal saponin derived from Allium victorialis var. platyphyllum, exhibiting cytotoxic inhibitory activity against cancer cells and being metabolized by human intestinal bacteria. Gitogenin 3-O-lycotetroside can be used in cancer research.

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CAS No.: 28591-01-7
화학식: C₅₀H₈₂O₂₃
분자량:1051.17

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gitogenin 3-O-lycotetroside Chemical Structure

CAS No.: 28591-01-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	17.9 μg/mL	Cytotoxicity against human hepatoblastoma HepG-2 cells assessed by MTT assay after 48 hrs of treatment. Cytotoxicity against human hepatoblastoma HepG-2 cells assessed by MTT assay after 48 hrs of treatment.	11235811
Vero	IC50	14.6 μg/mL	Cytotoxicity against monkey kidney Vero-P128 cells assessed by MTT assay after 48 hrs of treatment. Cytotoxicity against monkey kidney Vero-P128 cells assessed by MTT assay after 48 hrs of treatment.	11235811
P388	IC50	36.5 μg/mL	Cytotoxicity against mouse lymphoma leukemia P-388 cells assessed by MTT assay after 48 hrs of treatment. Cytotoxicity against mouse lymphoma leukemia P-388 cells assessed by MTT assay after 48 hrs of treatment.	11235811
L1210	IC50	6.5 μg/mL	Cytotoxicity against mouse lymphomatic leukemia L-1210 cells assessed by MTT assay after 48 hrs of treatment. Cytotoxicity against mouse lymphomatic leukemia L-1210 cells assessed by MTT assay after 48 hrs of treatment.	11235811

In Vitro

Gitogenin 3-O-lycotetroside (Serial dilutions; 48 h) exhibits potent cytotoxic activity in the range of 6.51-36.5 μg/mL across HepG-2, Vero-P128, P-388, and L-1210 cell lines, with the strongest potency observed against L-1210 cells (IC₅₀ = 6.5 μg/mL)^[1].
Incubation of gitogenin 3-O-lycotetroside (100 mg; 24 h) with human intestinal bacteria for 24 h at 37°C leads to the production of metabolites 3d and 3e, with the structure of 3e suggesting hydrolysis of the spiroketal ring E/F^[1].
Gitogenin 3-O-lycotetroside (2 mg; 24 h) is progressively degraded by human intestinal bacteria in a time-dependent manner, with metabolite 3e appearing at 6 h and metabolite 3d at 24 h^[1].
Gitogenin 3-O-lycotetroside (0.1-0.2 mg/mL; 24 h) reduces cell viability in HT-29 human colon cancer cells in a dose-dependent manner, with 68% inhibition observed at 0.2 mg/mL^[2].
Gitogenin 3-O-lycotetroside (0.01-0.2 mg/mL; 24 h) induces apoptotic morphological changes, including chromatin condensation and formation of apoptotic bodies, in HT-29 human colon cancer cells^[2].
Gitogenin 3-O-lycotetroside (0.01-0.2 mg/mL; 24 h) induces internucleosomal DNA fragmentation in HT-29 human colon cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

HT-29
Concentration:

0.1, 0.2 mg/mL
Incubation Time:

24 h
Result:

Reduced cell viability by 9% at 0.1 mg/mL and 68% at 0.2 mg/mL.

Apoptosis Analysis^[2]

Cell Line:

HT-29
Concentration:

0.01, 0.1, 0.2 mg/mL
Incubation Time:

24 h
Result:

Induced apoptotic morphological changes, including chromatin condensation and formation of apoptotic bodies.

Chemical Information

CAS No. 28591-01-7
분자량 1051.17
화학식 C₅₀H₈₂O₂₃
SMILES

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@@](C[C@H]([C@@H](C6)O)O[C@@H]7O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC5)C)([H])CC2
Structure Classification
- Steroids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lee KT, et al. Constituents and the antitumor principle of Allium victorialis var. platyphyllum. Archives of pharmacal research. 2001 Feb;24(1):44-50.

[2]. Kim HJ, et al. Chemopreventive and Anticancer Activities of Allium victorialis var. platyphyllum Extracts. Journal of cancer prevention. 2014 Sep;19(3):179-86.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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