HDAC3-IN-8
HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 2763368-90-5
- 화학식: C20H21N3O3
- 분자량:351.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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HDAC3 0.38 nM (IC50) |
HDAC1 3.52 nM (IC50) |
HDAC2 15.14 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
36.8 nM
Compound: 11i
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Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
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[PMID: 34942071] |
Chemical Information
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CAS No. 2763368-90-5
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분자량 351.40
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화학식 C20H21N3O3
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SMILES
O=C(C1=CC2=CC=CC=C2O1)NCC3=CC=C(C(NNCCC)=O)C=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC3-IN-8 Related Classifications
HY-181768 Related Classifications
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