country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-121372

Copy Link Print Information

Lactandrate

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI₅₀ value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 43000-65-3
화학식: C₃₁H₄₄Cl₂N₂O₃
분자량:563.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lactandrate Chemical Structure

CAS No.: 43000-65-3

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Estrogen Receptor/ERR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 h by MTT assay Growth inhibition of human MCF7 cells after 48 h by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 by MTT assay Growth inhibition of human MCF7 cells after 48 by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 h by MTT assay Growth inhibition of human T47D cells after 48 h by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 by MTT assay Growth inhibition of human T47D cells after 48 by MTT assay	[PMID: 29649739]

Chemical Information

CAS No. 43000-65-3
분자량 563.60
화학식 C₃₁H₄₄Cl₂N₂O₃
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Lactandrate

All Estrogen Receptor/ERR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Lactandrate Related Classifications

HY-121372 Related Classifications