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Cat. No.: HY-123004

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S 4404

S 4404 is a prolyl-4-hydroxylase inhibitor. S 4404 functions as a non-substrate of hepatobiliary transport systems. S 4404 undergoes metabolic breakdown into fluorescent and red-colored metabolites. S 4404 can be used for the research of liver fibrosis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 143199-54-6
화학식: C₂₈H₃₃N₇O₉
분자량:611.60

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

S 4404 Chemical Structure

CAS No.: 143199-54-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vivo

S 4404 (1 mM; i.v.; single bolus) is not transported in intact form from portal blood into bile, with less than 4% of the intact compound appearing in bile within 40 minutes of administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, 400-500 g)^[1]
Dosage:

1 mM
Administration:

i.v.; single bolus
Result:

Secreted less than 4% in intact form into bile within 40 minutes.
Secreted approximately 28% as metabolite M₂ into bile within 40 minutes.

Chemical Information

CAS No. 143199-54-6
분자량 611.60
화학식 C₂₈H₃₃N₇O₉
SMILES

[O-][N+](C(C1=NON=C21)=CC=C2NCCC(N[C@@H](CC3=CC=CC=C3)C(N4[C@H](C(NCC(OC(C)(C)C)=O)=O)CCO4)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kramer W, et al. Liver-specific drug targeting by coupling to bile acids. J Biol Chem. 1992 Sep 15;267(26):18598-604.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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