XR11576
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 346689-77-8
- 화학식: C23H24N4O2
- 분자량:388.46
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All Topoisomerase Isoforms
More
Biological Activity
제품 설명
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COR-L23 | IC50 |
10.1 nM
Compound: XR-11576
|
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
|
[PMID: 11806724] |
| COR-L23 | IC50 |
12.1 nM
Compound: XR-11576
|
Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)
|
[PMID: 11806724] |
| NCI-H69 | IC50 |
1.2 nM
Compound: 11
|
Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein
|
[PMID: 11806725] |
| NCI-H69 | IC50 |
23 nM
Compound: XR-11576
|
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
|
[PMID: 11806724] |
| NCI-H69 | IC50 |
23 nM
Compound: 11
|
Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)
|
[PMID: 11806725] |
| NCI-H69 | IC50 |
29 nM
Compound: XR-11576
|
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
|
[PMID: 11806724] |
| P388 | IC50 |
10 nM
Compound: 11
|
Inhibitory activity against murine P388 leukemia (P388) cells.
Inhibitory activity against murine P388 leukemia (P388) cells.
|
[PMID: 11806725] |
Chemical Information
-
CAS No. 346689-77-8
-
분자량 388.46
-
화학식 C23H24N4O2
-
SMILES
O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1
-
Synonyms
MLN576
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60. [Content Brief]
[2]. Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XR11576 Related Classifications
HY-123143 Related Classifications
Powered by Bioz