Lp(a)-IN-5 hydrochloride

Name: Lp(a)-IN-5 hydrochloride
Brand: MedChemExpress
SKU: HY-171464A
Rating: 4.5 (1 reviews)

Cat. No.: HY-171464A Purity: 99.70%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Lp(a)-IN-5 (Compound A) hydrochloride is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 hydrochloride inhibits the assembly of Apo(a) and ApoB proteins with an IC₅₀ value of 0.41 nM. Lp(a)-IN-5 hydrochloride is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases.

For research use only. We do not sell to patients.

Lp(a)-IN-5 hydrochloride Chemical Structure

CAS No. : 2924841-80-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lp(a)-IN-5 hydrochloride:

Lp(a)-IN-5 Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Apolipoprotein Isoform Specific Products:

View All Isoforms

apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Lp(a)-IN-5 hydrochloride inhibits the assembly of Apo(a) and ApoB proteins with an IC₅₀ value of 0.41 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	AUC	T_1/2
Dog^[1]	10 mg/kg	p.o.	2473 ng/mL	28594 ng·h/mL	18.3 h

Molecular Weight

886.77

Formula

C₄₃H₆₀Cl₄N₄O₇

CAS No.

2924841-80-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@H]([C@H]1CCNC1)CC2=CC=CC(CN(CC3=CC(C[C@H](C(O)=O)[C@H]4CCNC4)=CC=C3)CCOC5=CC(C[C@H](C(O)=O)[C@H]6CCNC6)=CC=C5)=C2.Cl.Cl.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (56.38 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1277 mL	5.6384 mL	11.2769 mL
5 mM	0.2255 mL	1.1277 mL	2.2554 mL
10 mM	0.1128 mL	0.5638 mL	1.1277 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (252 KB) HNMR (466 KB) RP-HPLC (239 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Yao JQ, et al. Crystal form of lipoprotein compound and preparation method therefor. WO2024230805A1. 2024-11-14.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1277 mL	5.6384 mL	11.2769 mL	28.1922 mL
	5 mM	0.2255 mL	1.1277 mL	2.2554 mL	5.6384 mL
	10 mM	0.1128 mL	0.5638 mL	1.1277 mL	2.8192 mL
	15 mM	0.0752 mL	0.3759 mL	0.7518 mL	1.8795 mL
	20 mM	0.0564 mL	0.2819 mL	0.5638 mL	1.4096 mL
	25 mM	0.0451 mL	0.2255 mL	0.4511 mL	1.1277 mL
	30 mM	0.0376 mL	0.1879 mL	0.3759 mL	0.9397 mL
	40 mM	0.0282 mL	0.1410 mL	0.2819 mL	0.7048 mL
	50 mM	0.0226 mL	0.1128 mL	0.2255 mL	0.5638 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.