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Cat. No.: HY-156230

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Man-GIcNAc-oxazoline

Man-GIcNAc-oxazoline is a disaccharide oxazoline based on Manβ1,4GlcNAc. Man-GIcNAc-oxazoline serves as a donor substrate for transglycosylation in endoglycosidase-mediated antibody Fc glycan remodeling. Man-GIcNAc-oxazoline can be modified with azides, PEG-linked azides, fluorescent probes, biotin groups, ligands or prodrugs. Man-GIcNAc-oxazoline can be used for the synthesis of antibody-drug conjugates (ADC). Man-GIcNAc-oxazoline is applicable for cancer research.

For research use only. We do not sell to patients.

CAS No.: 2855124-74-0
Formula: C₂₀H₃₄N₄O₁₂
Molecular Weight:522.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Man-GIcNAc-oxazoline Chemical Structure

CAS No.: 2855124-74-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Man-GlcNAc-oxazoline (Compound 6) derivatives (10-30 eq; 6 h) serve as efficient donor substrates for endoglycosidase-mediated one-pot antibody glycan remodeling, enabling the synthesis of well-defined, functionally active homogeneous site-specific modified antibodies (including antibody-drug conjugates ADCs and lysosome-targeting chimeras)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2855124-74-0
Molecular Weight 522.50
Formula C₂₀H₃₄N₄O₁₂
SMILES

OC[C@@H](O[C@@]1([H])[C@@](N=C(O1)C)([H])[C@H]2O)[C@H]2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)O)O)COCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang LX, Zhang X. An Fc glycan remodeling platform method for site-specific antibody conjugation and applications thereof. WO2022226420 A2. 2022 Oct 27.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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